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Bioprinted Lung Model for Respiratory Diseases
Bioprinted Lung Model for Respiratory Diseases
Bioprinted Retinal Tissue for Zika Disease Modeling
Bioprinted Retinal Tissue for Zika Disease Modeling
Bioprinted Skin Equivalents for Drug Testing
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Bioprinted Vascularized Neuroblastoma-on-Chip
Epidermis Model for Drug Discovery
Epidermis Model for Drug Discovery
High-Throughput Bioprinting of Liver Microtissues
High-Throughput Bioprinting of Liver Microtissues
Organoid Printing for Drug-Induced Liver Injury Testing
Organoid Printing for Drug-Induced Liver Injury Testing
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SCIENTIFIC PUBLICATIONS

You are researching: Styrene–Isobutylene–Styrene triblock copolymers (SIBS)
Matching entries: 1 /1
Cell Type Tissue and Organ Biofabrication Skin Tissue Engineering Drug Delivery Biological Molecules Solid Dosage Drugs Stem Cells Personalised Pharmaceuticals Inducend Pluripotent Stem Cells (IPSCs) Drug Discovery Cancer Cell Lines
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AUTHOR Hilgeroth, Philipp S. and Thümmler, Justus F. and Binder, Wolfgang H.
Title 3D Printing of Triamcinolone Acetonide in Triblock Copolymers of Styrene–Isobutylene–Styrene as a Slow-Release System [Abstract]
Year 2022
Journal/Proceedings Polymers
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DOI/URL URL DOI
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Abstract
Additive manufacturing has a wide range of applications and has opened up new methods of drug formulation, in turn achieving attention in medicine. We prepared styrene–isobutylene–styrene triblock copolymers (SIBS; Mn = 10 kDa–25 kDa, PDI 1,3–1,6) as a drug carrier for triamcinolone acetonide (TA), further processed by fused deposition modeling to create a solid drug release system displaying improved bioavailability and applicability. Living carbocationic polymerization was used to exert control over block length and polymeric architecture. Thermorheological properties of the SIBS polymer (22.3 kDa, 38 wt % S) were adjusted to the printability of SIBS/TA mixtures (1–5% of TA), generating an effective release system effective for more than 60 days. Continuous drug release and morphological investigations were conducted to probe the influence of the 3D printing process on the drug release, enabling 3D printing as a formulation method for a slow-release system of Triamcinolone.
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