BROCHURES / DOCUMENTATION

REGENHU One Pager
REGENHU One Pager
Print tools and workzones
Print tools and workzones
Biomaterial printing compatibility table
Biomaterial printing compatibility table
R-GEN 100 brochure
R-GEN 100 brochure
R-GEN 200 brochure
R-GEN 200 brochure
SHAPER brochure
SHAPER brochure
R-GEN 100 datasheet
R-GEN 100 datasheet
R-GEN 200 datasheet
R-GEN 200 datasheet
SHAPER datasheet
SHAPER datasheet
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APPLICATION NOTES

3D-Bioprinted Pediatric Soft Tissue Sarcoma Model
3D-Bioprinted Pediatric Soft Tissue Sarcoma Model
Bioprinted Brain-on-Chips for Neural Disease Modeling
Bioprinted Brain-on-Chips for Neural Disease Modeling
Beta Cell Microsphere Fabrication for Diabetes Treatment
Beta Cell Microsphere Fabrication for Diabetes Treatment
Biofabricated Skin Carcinoma Model
Biofabricated Skin Carcinoma Model
Bioprinted Lung Model for Respiratory Diseases
Bioprinted Lung Model for Respiratory Diseases
Bioprinted Retinal Tissue for Zika Disease Modeling
Bioprinted Retinal Tissue for Zika Disease Modeling
Bioprinted Skin Equivalents for Drug Testing
Bioprinted Skin Equivalents for Drug Testing
Bioprinted Vascularized Neuroblastoma-on-Chip
Bioprinted Vascularized Neuroblastoma-on-Chip
Epidermis Model for Drug Discovery
Epidermis Model for Drug Discovery
High-Throughput Bioprinting of Liver Microtissues
High-Throughput Bioprinting of Liver Microtissues
Metastatic Bone Models for Cancer Inhibitors Screening
Metastatic Bone Models for Cancer Inhibitors Screening
Organoid Printing for Drug-Induced Liver Injury Testing
Organoid Printing for Drug-Induced Liver Injury Testing
3D-Bioprinted Osteosarcoma Model for Drug Testing
3D-Bioprinted Osteosarcoma Model for Drug Testing
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SCIENTIFIC PUBLICATIONS

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Cell Type Tissue and Organ Biofabrication Skin Tissue Engineering Drug Delivery Biological Molecules Solid Dosage Drugs Stem Cells Personalised Pharmaceuticals Inducend Pluripotent Stem Cells (IPSCs) Drug Discovery Cancer Cell Lines
All Groups
AUTHOR Khaled, Shaban A. and Burley, Jonathan C. and Alexander, Morgan R. and Yang, Jing and Roberts, Clive J.
Title 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles [Abstract]
Year 2015
Journal/Proceedings Journal of Controlled Release
Reftype
DOI/URL URL DOI
Groups 
Abstract
Abstract We have used three dimensional (3D) extrusion printing to manufacture a multi-active solid dosage form or so called polypill. This contains five compartmentalised drugs with two independently controlled and well-defined release profiles. This polypill demonstrates that complex medication regimes can be combined in a single personalised tablet. This could potentially improve adherence for those patients currently taking many separate tablets and also allow ready tailoring of a particular drug combination/drug release for the needs of an individual. The polypill here represents a cardiovascular treatment regime with the incorporation of an immediate release compartment with aspirin and hydrochlorothiazide and three sustained release compartments containing pravastatin, atenolol, and ramipril. X-ray powder diffraction (XRPD) and Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) were used to assess drug-excipient interaction. The printed polypills were evaluated for drug release using {USP} dissolution testing. We found that the polypill showed the intended immediate and sustained release profiles based upon the active/excipient ratio used.
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