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You are researching: Liver tissue Engineering
Drug Delivery
Biological Molecules
Solid Dosage Drugs
Stem Cells
Personalised Pharmaceuticals
Inducend Pluripotent Stem Cells (IPSCs)
Drug Discovery
Cancer Cell Lines
Cell Type
Tissue and Organ Biofabrication
Skin Tissue Engineering
All Groups
- Cell Type
- Epithelial
- Neutrophils
- Adipocytes
- Human Umbilical Vein Endothelial Cells (HUVECs)
- Organoids
- Stem Cells
- Spheroids
- Meniscus Cells
- Synoviocytes
- Keratinocytes
- Skeletal Muscle-Derived Cells (SkMDCs)
- Neurons
- Macrophages
- Human Trabecular Meshwork Cells
- Endothelial
- CardioMyocites
- Melanocytes
- Retinal
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- Corneal Stromal Cells
- Fibroblasts
- β cells
- Myoblasts
- Pericytes
- Hepatocytes
- Cancer Cell Lines
- Bacteria
- Articular cartilage progenitor cells (ACPCs)
- Tenocytes
- Osteoblasts
- Monocytes
- Mesothelial cells
- Institution
- National University of Singapore
- CIC biomaGUNE
- Kaohsiung Medical University
- DTU – Technical University of Denmark
- Adolphe Merkle Institute Fribourg
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- Biomaterials & Bioinks
- Application
- Tissue and Organ Biofabrication
- Cartilage Tissue Engineering
- Bone Tissue Engineering
- Drug Delivery
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- Vascularization
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- Meniscus Tissue Engineering
- Heart – Cardiac Patches Tissue Engineering
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- Review Paper
- Printing Technology
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- Decellularized Extracellular Matrix (dECM)
- Metals
- Solid Dosage Drugs
- Thermoplastics
- Non-cellularized gels/pastes
- Acrylates
- Poly(Vinyl Formal)
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- poly (ethylene-co -vinyl acetate) (PEVA)
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- Poly(N-isopropylacrylamide) (PNIPAAm)
- Mineral Oil
- poly(octanediol-co-maleic anhydride-co-citrate) (POMaC)
- Poly(Oxazoline)
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- 2-hydroxyethyl) methacrylate (HEMA)
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- Polyisobutylene
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- Cellulose
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- Polyethylene glycol (PEG) based
- α-Bioink
- Collagen
- Elastin
- Heparin
- Gelatin
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- Methacrylated hyaluronic acid (HAMA)
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- Fibrinogen
- Fibrin
- Paeoniflorin
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- Methacrylated Collagen (CollMA)
- Carrageenan
- Glucosamine
- Chitosan
- Glycerol
- Poly(glycidol)
- Alginate
- Agarose
- Gelatin-Methacryloyl (GelMA)
- methacrylated chondroitin sulfate (CSMA)
- Ceramics
- Bioprinting Technologies
- Bioprinting Applications
AUTHOR
Title
Biocompatibility evaluation of antioxidant cocktail loaded gelatin methacrylamide as bioink for extrusion-based 3D bioprinting
[Abstract]
Year
2023
Journal/Proceedings
Biomedical Materials
Reftype
DOI/URL
DOI
Groups
AbstractThree-dimensional (3D) liver bioprinting is a promising technique for creating 3D liver models that can be used for in vitro drug testing, hepatotoxicity studies, and transplantation. The functional performance of 3D bioprinted liver constructs are limited by the lack of cell–cell interactions, which calls for the creation of bioprinted tissue constructs with high cell densities. This study reports the fabrication of 3D bioprinted liver constructs using a novel photocrosslinkable gelatin methacrylamide (GelMA)-based bioink formulation. However, the formation of excess free radicals during photoinitiation poses a challenge, particularly during photocrosslinking of large constructs with high cell densities. Hence, we designed a bioink formulation comprising the base polymer GelMA loaded with an antioxidant cocktail containing vitamin C (L-ascorbic acid (AA)) and vitamin E (α-tocopherol (α-Toc)). We confirmed that the combination of antioxidants loaded in GelMA enhanced the ability to scavenge intracellular reactive oxygen species formed during photocrosslinking. The GelMA formulation was evaluated for biocompatibility in vitro and in vivo. These results demonstrated that the bioink had adequate rheological characteristics and was biocompatible. Furthermore, when compared to bioprinted constructs with lower cell density, high-density primary rat hepatocyte constructs demonstrated improved cell-cell interactions and liver-specific functions like albumin and urea secretion, which increased 5-fold and 2.5-fold, respectively.