BROCHURES / DOCUMENTATION
APPLICATION NOTES
SCIENTIFIC PUBLICATIONS
You are researching: Liver tissue Engineering
Cell Type
Tissue and Organ Biofabrication
Skin Tissue Engineering
Drug Delivery
Biological Molecules
Solid Dosage Drugs
Stem Cells
Personalised Pharmaceuticals
Inducend Pluripotent Stem Cells (IPSCs)
Drug Discovery
Cancer Cell Lines
All Groups
- Printing Technology
- Biomaterial
- Ceramics
- Metals
- Bioinks
- Fibronectin
- Xanthan Gum
- Paeoniflorin
- Methacrylated Silk Fibroin
- Heparin
- Fibrinogen
- (2-Hydroxypropyl)methacrylamide (HPMA)
- Carrageenan
- Chitosan
- Glycerol
- Poly(glycidol)
- Agarose
- methacrylated chondroitin sulfate (CSMA)
- Silk Fibroin
- Methacrylated hyaluronic acid (HAMA)
- Gellan Gum
- Alginate
- Gelatin-Methacryloyl (GelMA)
- Cellulose
- Hyaluronic Acid
- Polyethylene glycol (PEG) based
- Collagen
- Gelatin
- Novogel
- Peptide gel
- α-Bioink
- Elastin
- Matrigel
- Methacrylated Chitosan
- Pectin
- Pyrogallol
- Fibrin
- Methacrylated Collagen (CollMA)
- Glucosamine
- Non-cellularized gels/pastes
- 2-hydroxyethyl) methacrylate (HEMA)
- Paraffin
- Polyphenylene Oxide
- Acrylamide
- SEBS
- Ionic Liquids
- Jeffamine
- Mineral Oil
- Salecan
- Zein
- poly(octanediol-co-maleic anhydride-co-citrate) (POMaC)
- Poly(itaconate-co-citrate-cooctanediol) (PICO)
- Polyvinylpyrrolidone (PVP)
- Salt-based
- Acrylates
- 2-hydroxyethyl-methacrylate (HEMA)
- Magnetorheological fluid (MR fluid – MRF)
- Poly(vinyl alcohol) (PVA)
- PEDOT
- Polyethylene
- Silicone
- Pluronic – Poloxamer
- Carbopol
- Epoxy
- poly (ethylene-co -vinyl acetate) (PEVA)
- Phenylacetylene
- Poly(N-isopropylacrylamide) (PNIPAAm)
- Poly(Oxazoline)
- Poly(trimethylene carbonate)
- Polyisobutylene
- Konjac Gum
- Gelatin-Sucrose Matrix
- Chlorella Microalgae
- Poly(Vinyl Formal)
- Thermoplastics
- Micro/nano-particles
- Biological Molecules
- Decellularized Extracellular Matrix (dECM)
- Solid Dosage Drugs
- Review Paper
- Application
- Tissue Models – Drug Discovery
- BioSensors
- Personalised Pharmaceuticals
- In Vitro Models
- Bioelectronics
- Industrial
- Robotics
- Medical Devices
- Electronics – Robotics – Industrial
- Biomaterial Processing
- Tissue and Organ Biofabrication
- Liver tissue Engineering
- Muscle Tissue Engineering
- Nerve – Neural Tissue Engineering
- Meniscus Tissue Engineering
- Heart – Cardiac Patches Tissue Engineering
- Adipose Tissue Engineering
- Trachea Tissue Engineering
- Ocular Tissue Engineering
- Intervertebral Disc (IVD) Tissue Engineering
- Vascularization
- Skin Tissue Engineering
- Drug Delivery
- Cartilage Tissue Engineering
- Bone Tissue Engineering
- Drug Discovery
- Institution
- Myiongji University
- Hong Kong University
- Veterans Administration Medical Center
- University of Applied Sciences Northwestern Switzerland
- University of Michigan, Biointerfaces Institute
- Sree Chitra Tirunal Institute
- Kaohsiung Medical University
- Baylor College of Medicine
- L'Oreal
- University of Bordeaux
- KU Leuven
- Abu Dhabi University
- University of Sheffield
- DTU – Technical University of Denmark
- Hefei University
- Rice University
- University of Barcelona
- INM – Leibniz Institute for New Materials
- University of Nantes
- Institute for Bioengineering of Catalonia (IBEC)
- University of Amsterdam
- Bayreuth University
- Ghent University
- National University of Singapore
- Adolphe Merkle Institute Fribourg
- Zurich University of Applied Sciences (ZHAW)
- Hallym University
- University of Wurzburg
- AO Research Institute (ARI)
- Chalmers University of Technology
- ETH Zurich
- Nanyang Technological University
- Utrecht Medical Center (UMC)
- University of Manchester
- University of Nottingham
- Trinity College
- National Institutes of Health (NIH)
- Rizzoli Orthopaedic Institute
- University of Bucharest
- Innotere
- Nanjing Medical University
- Ningbo Institute of Materials Technology and Engineering (NIMTE)
- Queen Mary University
- Royal Free Hospital
- SINTEF
- University of Central Florida
- University of Freiburg
- Halle-Wittenberg University
- CIC biomaGUNE
- Chiao Tung University
- University of Geneva
- Novartis
- Karlsruhe institute of technology
- Shanghai University
- Technical University of Dresden
- University of Michigan – School of Dentistry
- University of Tel Aviv
- Aschaffenburg University
- Univerity of Hong Kong
- Chinese Academy of Sciences
- Helmholtz Institute for Pharmaceutical Research Saarland
- Brown University
- Innsbruck University
- National Yang Ming Chiao Tung University
- Tiangong University
- Harbin Institute of Technology
- Montreal University
- Anhui Polytechnic
- Jiao Tong University
- University of Toronto
- Politecnico di Torino
- Biomaterials & Bioinks
- Bioprinting Technologies
- Bioprinting Applications
- Cell Type
- Organoids
- Meniscus Cells
- Skeletal Muscle-Derived Cells (SkMDCs)
- Hepatocytes
- Monocytes
- Neutrophils
- Macrophages
- Corneal Stromal Cells
- Mesothelial cells
- Adipocytes
- Synoviocytes
- Human Trabecular Meshwork Cells
- Epithelial
- Human Umbilical Vein Endothelial Cells (HUVECs)
- Spheroids
- Keratinocytes
- Neurons
- Endothelial
- CardioMyocites
- Osteoblasts
- Articular cartilage progenitor cells (ACPCs)
- Cancer Cell Lines
- Chondrocytes
- Fibroblasts
- Myoblasts
- Melanocytes
- Retinal
- Embrionic Kidney (HEK)
- β cells
- Pericytes
- Bacteria
- Tenocytes
- Stem Cells
AUTHOR
Title
Biocompatibility evaluation of antioxidant cocktail loaded gelatin methacrylamide as bioink for extrusion-based 3D bioprinting
[Abstract]
Year
2023
Journal/Proceedings
Biomedical Materials
Reftype
DOI/URL
DOI
Groups
AbstractThree-dimensional (3D) liver bioprinting is a promising technique for creating 3D liver models that can be used for in vitro drug testing, hepatotoxicity studies, and transplantation. The functional performance of 3D bioprinted liver constructs are limited by the lack of cell–cell interactions, which calls for the creation of bioprinted tissue constructs with high cell densities. This study reports the fabrication of 3D bioprinted liver constructs using a novel photocrosslinkable gelatin methacrylamide (GelMA)-based bioink formulation. However, the formation of excess free radicals during photoinitiation poses a challenge, particularly during photocrosslinking of large constructs with high cell densities. Hence, we designed a bioink formulation comprising the base polymer GelMA loaded with an antioxidant cocktail containing vitamin C (L-ascorbic acid (AA)) and vitamin E (α-tocopherol (α-Toc)). We confirmed that the combination of antioxidants loaded in GelMA enhanced the ability to scavenge intracellular reactive oxygen species formed during photocrosslinking. The GelMA formulation was evaluated for biocompatibility in vitro and in vivo. These results demonstrated that the bioink had adequate rheological characteristics and was biocompatible. Furthermore, when compared to bioprinted constructs with lower cell density, high-density primary rat hepatocyte constructs demonstrated improved cell-cell interactions and liver-specific functions like albumin and urea secretion, which increased 5-fold and 2.5-fold, respectively.