You are researching: poly (ethylene-co -vinyl acetate) (PEVA)
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AUTHOR Li, Ming-Chia and Chang, Pu-Yuan and Luo, Huai-Rou and Chang, Ling-Yuan and Lin, Chuan-Yi and Yang, Chih-Yu and Lee, Oscar Kuang-Sheng and Lee, Yan-Hwa Wu and Tarng, Der-Cherng
Title Functioning tailor-made 3D-printed vascular graft for hemodialysis [Abstract]
Year 2022
Journal/Proceedings The Journal of Vascular Access
Background:The two ends of arteriovenous graft (AVG) are anastomosed to the upper limb vessels by surgery for hemodialysis therapy. However, the size of upper limb vessels varies to a large extent among different individuals.Methods:According to the shape and size of neck vessels quantified from the preoperative computed tomography angiographic scan, the ethylene-vinyl acetate (EVA)-based AVG was produced in H-shape by the three-dimensional (3D) printer and then sterilized. This study investigated the function of this novel 3D-printed AVG in vitro and in vivo.Results:This 3D-printed AVG can be implanted in the rabbit’s common carotid artery and common jugular vein with ease and functions in vivo. The surgical procedure was quick, and no suture was required. The blood loss was minimal, and no hematoma was noted at least 1 week after the surgery. The blood flow velocity within the implanted AVG was 14.9 ± 3.7 cm/s. Additionally, the in vitro characterization experiments demonstrated that this EVA-based biomaterial is biocompatible and possesses a superior recovery property than ePTFE after hemodialysis needle cannulation.Conclusions:Through the 3D printing technology, the EVA-based AVG can be tailor-made to fit the specific vessel size. This kind of 3D-printed AVG is functioning in vivo, and our results realize personalized vascular implants. Further large-animal studies are warranted to examine the long-term patency.
AUTHOR Huang, Yun-An and Ho, Chris T. and Lin, Yu-Hsuan and Lee, Chen-Ju and Ho, Szu-Mo and Li, Ming-Chia and Hwang, Eric
Title Nanoimprinted Anisotropic Topography Preferentially Guides Axons and Enhances Nerve Regeneration [Abstract]
Year 2018
Journal/Proceedings Macromolecular Bioscience
Abstract Surface topography has a profound effect on the development of the nervous system, such as neuronal differentiation and morphogenesis. While the interaction of neurons and the surface topography of their local environment is well characterized, the neuron–topography interaction during the regeneration process remains largely unknown. To address this question, an anisotropic surface topography resembling linear grooves made from poly(ethylene-vinyl acetate) (EVA), a soft and biocompatible polymer, using nanoimprinting, is established. It is found that neurons from both the central and peripheral nervous system can survive and grow on this grooved surface. Additionally, it is observed that axons but not dendrites specifically align with these grooves. Furthermore, it is demonstrated that neurons on the grooved surface are capable of regeneration after an on-site injury. More importantly, these injured neurons have an accelerated and enhanced regeneration. Together, the data demonstrate that this anisotropic topography guides axon growth and improves axon regeneration. This opens up the possibility to study the effect of surface topography on regenerating axons and has the potential to be developed into a medical device for treating peripheral nerve injuries.