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You are researching: Methacrylated Collagen (CollMA)
Skin Tissue Engineering
Drug Delivery
Biological Molecules
Solid Dosage Drugs
Stem Cells
Personalised Pharmaceuticals
Inducend Pluripotent Stem Cells (IPSCs)
Drug Discovery
Cancer Cell Lines
Cell Type
Tissue and Organ Biofabrication
All Groups
- Bioprinting Applications
- Cell Type
- Cancer Cell Lines
- Bacteria
- Epicardial Cells
- Articular cartilage progenitor cells (ACPCs)
- Tenocytes
- Extracellular Vesicles
- Osteoblasts
- Monocytes
- Mesothelial cells
- Nucleus Pulposus Cells
- Epithelial
- Neutrophils
- Adipocytes
- Smooth Muscle Cells
- T cells
- Human Umbilical Vein Endothelial Cells (HUVECs)
- Organoids
- Stem Cells
- Spheroids
- Meniscus Cells
- Synoviocytes
- Keratinocytes
- Skeletal Muscle-Derived Cells (SkMDCs)
- Neurons
- Macrophages
- Human Trabecular Meshwork Cells
- Endothelial
- CardioMyocites
- Melanocytes
- Retinal
- Chondrocytes
- Embrionic Kidney (HEK)
- Corneal Stromal Cells
- Annulus Fibrosus Cells
- Fibroblasts
- β cells
- Astrocytes
- Myoblasts
- Pericytes
- Hepatocytes
- Institution
- University of Amsterdam
- University of Tel Aviv
- University of Applied Sciences Northwestern Switzerland
- Anhui Polytechnic
- University Children's Hospital Zurich
- Bayreuth University
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- University of Michigan, Biointerfaces Institute
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- University of Sheffield
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- Biomaterials & Bioinks
- Application
- Biomaterial Processing
- Tissue Models – Drug Discovery
- Industrial
- Drug Discovery
- In Vitro Models
- Robotics
- Electronics – Robotics – Industrial
- Medical Devices
- Tissue and Organ Biofabrication
- Liver tissue Engineering
- Cartilage Tissue Engineering
- Bone Tissue Engineering
- Dental Tissue Engineering
- Drug Delivery
- Urethra Tissue Engineering
- Skin Tissue Engineering
- Uterus Tissue Engineering
- Nerve – Neural Tissue Engineering
- Meniscus Tissue Engineering
- Heart – Cardiac Patches Tissue Engineering
- Adipose Tissue Engineering
- Trachea Tissue Engineering
- Ocular Tissue Engineering
- Intervertebral Disc (IVD) Tissue Engineering
- Muscle Tissue Engineering
- BioSensors
- Personalised Pharmaceuticals
- Bioelectronics
- Review Paper
- Printing Technology
- Biomaterial
- Bioinks
- Poly(glycidol)
- Alginate
- Agarose
- Gelatin-Methacryloyl (GelMA)
- methacrylated chondroitin sulfate (CSMA)
- Cellulose
- Novogel
- carboxybetaine acrylamide (CBAA)
- Hyaluronic Acid
- Peptide gel
- Methacrylated Silk Fibroin
- Pantoan Methacrylate
- Polyethylene glycol (PEG) based
- α-Bioink
- Poly(Acrylic Acid)
- Collagen
- Elastin
- Heparin
- sulfobetaine methacrylate (SBMA)
- Gelatin
- Matrigel
- Gellan Gum
- Methacrylated Chitosan
- Methacrylated hyaluronic acid (HAMA)
- Pectin
- Silk Fibroin
- Pyrogallol
- Xanthan Gum
- Fibrinogen
- Fibrin
- Paeoniflorin
- Fibronectin
- (2-Hydroxypropyl)methacrylamide (HPMA)
- Methacrylated Collagen (CollMA)
- Carrageenan
- Glucosamine
- Chitosan
- Glycerol
- Ceramics
- Decellularized Extracellular Matrix (dECM)
- Metals
- Solid Dosage Drugs
- Thermoplastics
- Coaxial Extruder
- Non-cellularized gels/pastes
- Silicone
- Konjac Gum
- Polyphenylene Oxide
- Ionic Liquids
- Polyvinylpyrrolidone (PVP)
- Gelatin-Sucrose Matrix
- Salt-based
- Chlorella Microalgae
- Acrylates
- Poly(Vinyl Formal)
- 2-hydroxyethyl-methacrylate (HEMA)
- Phenylacetylene
- Magnetorheological fluid (MR fluid – MRF)
- Salecan
- Poly(vinyl alcohol) (PVA)
- PEDOT
- Jeffamine
- Poly(methyl methacrylate) (PMMA)
- Polyethylene
- SEBS
- Polypropylene Oxide (PPO)
- Carbopol
- Sucrose Acetate
- Epoxy
- poly (ethylene-co -vinyl acetate) (PEVA)
- Poly(itaconate-co-citrate-cooctanediol) (PICO)
- Poly(N-isopropylacrylamide) (PNIPAAm)
- Mineral Oil
- poly(octanediol-co-maleic anhydride-co-citrate) (POMaC)
- Poly(Oxazoline)
- Poly(trimethylene carbonate)
- 2-hydroxyethyl) methacrylate (HEMA)
- Zein
- Acrylamide
- Pluronic – Poloxamer
- Polyisobutylene
- Paraffin
- Micro/nano-particles
- Biological Molecules
- Bioinks
- Bioprinting Technologies
AUTHOR
Title
3D bioprinted breast cancer model reveals stroma-mediated modulation of extracellular matrix and radiosensitivity
[Abstract]
Year
2024
Journal/Proceedings
Bioactive Materials
Reftype
Groups
AbstractDeciphering breast cancer treatment resistance remains hindered by the lack of models that can successfully capture the four-dimensional dynamics of the tumor microenvironment. Here, we show that microextrusion bioprinting can reproducibly generate distinct cancer and stromal compartments integrating cells relevant to human pathology. Our findings unveil the functional maturation of this millimeter-sized model, showcasing the development of a hypoxic cancer core and an increased surface proliferation. Maturation was also driven by the presence of cancer-associated fibroblasts (CAF) that induced elevated microvascular-like structures complexity. Such modulation was concomitant to extracellular matrix remodeling, with high levels of collagen and matricellular proteins deposition by CAF, simultaneously increasing tumor stiffness and recapitulating breast cancer fibrotic development. Importantly, our bioprinted model faithfully reproduced response to treatment, further modulated by CAF. Notably, CAF played a protective role for cancer cells against radiotherapy, facilitating increased paracrine communications. This model holds promise as a platform to decipher interactions within the microenvironment and evaluate stroma-targeted drugs in a context relevant to human pathology.
AUTHOR
Title
A 3D multi-cellular tissue model of the human omentum to study the formation of ovarian cancer metastasis
[Abstract]
Year
2023
Journal/Proceedings
Biomaterials
Reftype
Groups
AbstractReliable and predictive experimental models are urgently needed to study metastatic mechanisms of ovarian cancer cells in the omentum. Although models for ovarian cancer cell adhesion and invasion were previously investigated, the lack of certain omental cell types, which influence the metastatic behavior of cancer cells, limits the application of these tissue models. Here, we describe a 3D multi-cellular human omentum tissue model, which considers the spatial arrangement of five omental cell types. Reproducible tissue models were fabricated combining permeable cell culture inserts and bioprinting technology to mimic metastatic processes of immortalized and patient-derived ovarian cancer cells. The implementation of an endothelial barrier further allowed studying the interaction between cancer and endothelial cells during hematogenous dissemination and the impact of chemotherapeutic drugs. This proof-of-concept study may serve as a platform for patient-specific investigations in personalized oncology in the future.
AUTHOR
Title
Harnessing Human Placental Membrane-Derived Bioinks: Characterization and Applications in Bioprinting and Vasculogenesis
[Abstract]
Year
2023
Journal/Proceedings
Advanced Healthcare Materials
Reftype
DOI/URL
DOI
Groups
AbstractAbstract Bioprinting applications in the clinical field generate great interest, but developing suitable biomaterial inks for medical settings is a challenge. Placental tissues offer a promising solution due to their abundance, stability, and status as medical waste. They contain basement membrane components, have a clinical history, and support angiogenesis. This study formulates bioinks from two placental tissues, amnion (AM) and chorion (CHO), and compares their unique extracellular matrix (ECM) and growth factor compositions. Rheological properties of the bioinks are evaluated for bioprinting and maturation of human endothelial cells. Both AM and Cho-derived bioinks sustained human endothelial cell viability, proliferation, and maturation, promoting optimal vasculogenesis. These bioinks derived from human sources have significant potential for tissue engineering applications, particularly in supporting vasculogenesis. This research contributes to the advancement of tissue engineering and regenerative medicine, bringing everyone closer to clinically viable bioprinting solutions using placental tissues as valuable biomaterials.
AUTHOR
Title
Extracellular matrix (ECM)-derived bioinks designed to foster vasculogenesis and neurite outgrowth: Characterization and bioprinting
[Abstract]
Year
2021
Journal/Proceedings
Bioprinting
Reftype
Groups
AbstractThe field of bioprinting has shown a tremendous development in recent years, focusing on the development of advanced in vitro models and on regeneration approaches. In this scope, the lack of suitable biomaterials that can be efficiently formulated as printable bioinks, while supporting specific cellular events, is currently considered as one of the main limitations in the field. Indeed, extracellular matrix (ECM)-derived biomaterials formulated to enable printability and support cellular response, for instance via integrin binding, are eagerly awaited in the field of bioprinting. Several bioactive laminin sequences, including peptides such as YIGSR and IKVAV, have been identified to promote endothelial cell attachment and/or neurite outgrowth and guidance, respectively. Here, we show the development of two distinct bioinks, designed to foster vasculogenesis or neurogenesis, based on methacrylated collagen and hyaluronic acid (CollMA and HAMA, respectively), both relevant ECM-derived polymers, and on their combination with cysteine-flanked laminin-derived peptides. Using this strategy, it was possible to optimize the bioink printability, by tuning CollMA and HAMA concentration and ratio, and modulate their bioactivity, through adjustments in the cell-active peptide sequence spatial density, without compromising cell viability. We demonstrated that cell-specific bioinks could be customized for the bioprinting of both human umbilical vein cord endothelial cells (HUVECs) or adult rat sensory neurons from the dorsal root ganglia, and could stimulate both vasculogenesis and neurite outgrowth, respectively. This approach holds great potential as it can be tailored to other cellular models, due to its inherent capacity to accommodate different peptide compositions and to generate complex peptide mixtures and/or gradients.