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You are researching: Lung Carcinoma
Solid Dosage Drugs
Stem Cells
Personalised Pharmaceuticals
Inducend Pluripotent Stem Cells (IPSCs)
Drug Discovery
Cancer Cell Lines
Cell Type
Tissue and Organ Biofabrication
Skin Tissue Engineering
Drug Delivery
Biological Molecules
All Groups
- Cell Type
- Human Umbilical Vein Endothelial Cells (HUVECs)
- Organoids
- Stem Cells
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- Keratinocytes
- Skeletal Muscle-Derived Cells (SkMDCs)
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- Articular cartilage progenitor cells (ACPCs)
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- Mesothelial cells
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- Institution
- Adolphe Merkle Institute Fribourg
- Halle-Wittenberg University
- Baylor College of Medicine
- INM – Leibniz Institute for New Materials
- National Yang Ming Chiao Tung University
- Zurich University of Applied Sciences (ZHAW)
- Innotere
- L'Oreal
- Tiangong University
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- Biomaterials & Bioinks
- Application
- Personalised Pharmaceuticals
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- Tissue Models – Drug Discovery
- Industrial
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- Electronics – Robotics – Industrial
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- Tissue and Organ Biofabrication
- Cartilage Tissue Engineering
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- Review Paper
- Printing Technology
- Biomaterial
- Solid Dosage Drugs
- Thermoplastics
- Non-cellularized gels/pastes
- 2-hydroxyethyl-methacrylate (HEMA)
- Phenylacetylene
- Magnetorheological fluid (MR fluid – MRF)
- Salecan
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- poly(octanediol-co-maleic anhydride-co-citrate) (POMaC)
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- Biological Molecules
- Bioinks
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- α-Bioink
- Collagen
- Elastin
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- Pectin
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- Fibrinogen
- Fibrin
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- Methacrylated Collagen (CollMA)
- Carrageenan
- Glucosamine
- Chitosan
- Glycerol
- Poly(glycidol)
- Alginate
- Agarose
- Gelatin-Methacryloyl (GelMA)
- methacrylated chondroitin sulfate (CSMA)
- Cellulose
- Novogel
- Ceramics
- Decellularized Extracellular Matrix (dECM)
- Metals
- Bioprinting Technologies
- Bioprinting Applications
AUTHOR
Title
Development and evaluation of a multicomponent bioink consisting of alginate, gelatin, diethylaminoethyl cellulose and collagen peptide for 3D bioprinting of tissue construct for drug screening application
[Abstract]
Year
2022
Journal/Proceedings
International Journal of Biological Macromolecules
Reftype
Groups
AbstractThree dimensional (3D) bioprinting technology has been making a progressive advancement in the field of tissue engineering to produce tissue constructs that mimic the shape, framework, and microenvironment of an organ. The technology has not only paved the way to organ development but has been widely studied for its application in drug and cosmetic testing using 3D bioprinted constructs. However, not much has been explored on the utilization of bioprinting technology for the development of tumor models to test anti-cancer drug efficacy. The conventional methodology involves a two dimensional (2D) monolayer model to test cellular drug response which has multiple limitations owing to its inability to mimic the natural tissue environment. The choice of bioink for 3D bioprinting is critical as cell morphology and proliferation depend greatly on the property of bioink. In this study, we developed a multicomponent bioink composed of alginate, diethylaminoethyl cellulose, gelatin, and collagen peptide to generate a 3D bioprinted construct. The bioink has been characterised and validated for its printability, shape fidelity and biocompatibility to be used for generating tumor models. Further, a bioprinted tumor model was developed using lung cancer cell line and the efficacy of 3D printed construct for drug screening application was established.