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You are researching: Platelet-Rich Plasma
Inducend Pluripotent Stem Cells (IPSCs)
Drug Discovery
Cancer Cell Lines
Cell Type
Tissue and Organ Biofabrication
Skin Tissue Engineering
Drug Delivery
Biological Molecules
Solid Dosage Drugs
Stem Cells
Personalised Pharmaceuticals
All Groups
- Printing Technology
- Biomaterial
- Ceramics
- Metals
- Bioinks
- Fibronectin
- Xanthan Gum
- Paeoniflorin
- Methacrylated Silk Fibroin
- Heparin
- Fibrinogen
- (2-Hydroxypropyl)methacrylamide (HPMA)
- Carrageenan
- Chitosan
- Glycerol
- Poly(glycidol)
- Agarose
- methacrylated chondroitin sulfate (CSMA)
- Silk Fibroin
- Methacrylated hyaluronic acid (HAMA)
- Gellan Gum
- Alginate
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- Intervertebral Disc (IVD) Tissue Engineering
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- Drug Delivery
- Cartilage Tissue Engineering
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- Institution
- Myiongji University
- Hong Kong University
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- University of Applied Sciences Northwestern Switzerland
- University of Michigan, Biointerfaces Institute
- Sree Chitra Tirunal Institute
- Kaohsiung Medical University
- Baylor College of Medicine
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- Biomaterials & Bioinks
- Bioprinting Technologies
- Bioprinting Applications
- Cell Type
- Organoids
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AUTHOR
Title
Addition of Platelet-Rich Plasma to Silk Fibroin Hydrogel Bioprinting for Cartilage Regeneration
[Abstract]
Year
2020
Journal/Proceedings
Tissue Engineering Part A
Reftype
DOI/URL
DOI
Groups
AbstractThe recent advent of 3D bioprinting of biopolymers provides a novel method for fabrication of tissue-engineered scaffolds and also offers a potentially promising avenue in cartilage regeneration. Silk fibroin (SF) is one of the most popular biopolymers used for 3D bioprinting, but further application of SF is hindered by its limited biological activities. Incorporation of growth factors (GFs) has been identified as a solution to improve biological function. Platelet-rich plasma (PRP) is an autologous resource of GFs, which has been widely used in clinic. In this study, we have developed SF-based bioinks incorporated with different concentrations of PRP (12.5%, 25%, and 50%; vol/vol). Release kinetic studies show that SF-PRP bioinks could achieve controlled release of GFs. Subsequently, SF-PRP bioinks were successfully fabricated into scaffolds by bioprinting. Our results revealed that SF-PRP scaffolds possessed proper internal pore structure, good biomechanical properties, and a suitable degradation rate for cartilage regeneration. Live/dead staining showed that 3D, printed SF-PRP scaffolds were biocompatible. Moreover, in vitro studies revealed that tissue-engineered cartilage from the SF-PRP group exhibited improved qualities compared with the pure SF controls, according to histological and immunohistochemical findings. Biochemical evaluations confirmed that SF-PRP (50% PRP, v/v) scaffolds allowed the largest increases in collagen and glycosaminoglycan concentrations, when compared with the pure SF group. These findings suggest that 3D, printed SF-PRP scaffolds could be potential candidates for cartilage tissue engineering.
AUTHOR
Title
Formulation and Characterization of Alginate Dialdehyde, Gelatin, and Platelet-Rich Plasma-Based Bioink for Bioprinting Applications
[Abstract]
Year
2020
Journal/Proceedings
Bioengineering
Reftype
Groups
AbstractLayer-by-layer additive manufacturing process has evolved into three-dimensional (3D) “bio-printing” as a means of constructing cell-laden functional tissue equivalents. The process typically involves the mixing of cells of interest with an appropriate hydrogel, termed as “bioink”, followed by printing and tissue maturation. An ideal bioink should have adequate mechanical, rheological, and biological features of the target tissues. However, native extracellular matrix (ECM) is made of an intricate milieu of soluble and non-soluble extracellular factors, and mimicking such a composition is challenging. To this end, here we report the formulation of a multi-component bioink composed of gelatin and alginate -based scaffolding material, as well as a platelet-rich plasma (PRP) suspension, which mimics the insoluble and soluble factors of native ECM respectively. Briefly, sodium alginate was subjected to controlled oxidation to yield alginate dialdehyde (ADA), and was mixed with gelatin and PRP in various volume ratios in the presence of borax. The formulation was systematically characterized for its gelation time, swelling, and water uptake, as well as its morphological, chemical, and rheological properties; furthermore, blood- and cytocompatibility were assessed as per ISO 10993 (International Organization for Standardization). Printability, shape fidelity, and cell-laden printing was evaluated using the RegenHU 3D Discovery bioprinter. The results indicated the successful development of ADA–gelatin–PRP based bioink for 3D bioprinting and biofabrication applications.