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You are researching: Muscle Tissue Engineering
Cancer Cell Lines
Cell Type
Tissue and Organ Biofabrication
Skin Tissue Engineering
Drug Delivery
Biological Molecules
Solid Dosage Drugs
Stem Cells
Personalised Pharmaceuticals
Inducend Pluripotent Stem Cells (IPSCs)
Drug Discovery
All Groups
- Bioprinting Technologies
- Bioprinting Applications
- Cell Type
- Fibroblasts
- β cells
- Myoblasts
- Pericytes
- Cancer Cell Lines
- Bacteria
- Articular cartilage progenitor cells (ACPCs)
- Tenocytes
- Osteoblasts
- Monocytes
- Mesothelial cells
- Epithelial
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- Human Trabecular Meshwork Cells
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- University of Wurzburg
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- Biomaterials & Bioinks
- Application
- Biomaterial Processing
- Tissue Models – Drug Discovery
- Drug Discovery
- Electronics – Robotics – Industrial
- Tissue and Organ Biofabrication
- Ocular Tissue Engineering
- Intervertebral Disc (IVD) Tissue Engineering
- Muscle Tissue Engineering
- Cartilage Tissue Engineering
- Bone Tissue Engineering
- Drug Delivery
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- Vascularization
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- Heart – Cardiac Patches Tissue Engineering
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- BioSensors
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- Review Paper
- Printing Technology
- Biomaterial
- Non-cellularized gels/pastes
- Poly(trimethylene carbonate)
- 2-hydroxyethyl) methacrylate (HEMA)
- Zein
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- Polyisobutylene
- Paraffin
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- Konjac Gum
- Polyphenylene Oxide
- Ionic Liquids
- Polyvinylpyrrolidone (PVP)
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- Salt-based
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- 2-hydroxyethyl-methacrylate (HEMA)
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- poly (ethylene-co -vinyl acetate) (PEVA)
- Poly(itaconate-co-citrate-cooctanediol) (PICO)
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- Gelatin-Methacryloyl (GelMA)
- methacrylated chondroitin sulfate (CSMA)
- Cellulose
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- Hyaluronic Acid
- Peptide gel
- Methacrylated Silk Fibroin
- Polyethylene glycol (PEG) based
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- Collagen
- Elastin
- Heparin
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- Gellan Gum
- Methacrylated Chitosan
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- Pectin
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- (2-Hydroxypropyl)methacrylamide (HPMA)
- Methacrylated Collagen (CollMA)
- Carrageenan
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- Thermoplastics
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AUTHOR
Title
Functional Skeletal Muscle Regeneration Using Muscle Mimetic Tissue Fabricated by Microvalve-Assisted Coaxial 3D Bioprinting
[Abstract]
Year
2022
Journal/Proceedings
Advanced Healthcare Materials
Reftype
DOI/URL
DOI
Groups
AbstractAbstract 3D-printed artificial skeletal muscle, which mimics the structural and functional characteristics of native skeletal muscle, is a promising treatment method for muscle reconstruction. Although various fabrication techniques for skeletal muscle using 3D bio-printers are studied, it is still challenging to build a functional muscle structure. A strategy using microvalve-assisted coaxial 3D bioprinting in consideration of functional skeletal muscle fabrication is reported. The unit (artificial muscle fascicle: AMF) of muscle mimetic tissue is composed of a core filled with medium-based C2C12 myoblast aggregates as a role of muscle fibers and a photo cross-linkable hydrogel-based shell as a role of connective tissue in muscles that enhances printability and cell adhesion and proliferation. Especially, a microvalve system is applied for the core part with even cell distribution and strong cell–cell interaction. This system enhances myotube formation and consequently shows spontaneous contraction. A multi-printed AMF (artificial muscle tissue: AMT) as a piece of muscle is implanted into the anterior tibia (TA) muscle defect site of immunocompromised rats. As a result, the TA-implanted AMT responds to electrical stimulation and represents histologically regenerated muscle tissue. This microvalve-assisted coaxial 3D bioprinting shows a significant step forward to mimicking native skeletal muscle tissue.
AUTHOR
Year
2018
Journal/Proceedings
Bioprinting
Reftype
Groups
AbstractConducting polymeric materials have been used to modulate response of cells seeded on their surfaces. However, there is still major improvement to be made related to their biocompatibility, conductivity, stability in biological milieu, and processability toward truly tissue engineered functional device. In this work, conductive polymer, poly(3,4-ethylene-dioxythiophene):polystyrene-sulfonate (PEDOT:PSS), and its possible applications in tissue engineering were explored. In particular PEDOT:PSS solution was inkjet printed onto a gelatin substrate for obtaining a conductive structure. Mechanical and electrical characterizations, structural stability by swelling and degradation tests were carried out on different PEDOT-based samples obtained by varying the number of printed PEDOT layers from 5 to 50 on gelatin substrate. Biocompatibility of substrates was investigated on C2C12 myoblasts, through metabolic activity assay and imaging analysis during a 7-days culture period, to assess cell morphology, differentiation and alignment. The results of this first part allowed to proceed with the second part of the study in which these substrates were used for the design of an electrical stimulation device, with the aim of providing the external stimulus (3 V amplitude square wave at 1 and 2 Hz frequency) to guide myotubes alignment and enhance differentiation, having in this way promising applications in the field of muscle tissue engineering.
AUTHOR
Title
Composite Biomaterials as Long-Lasting Scaffolds for 3D Bioprinting of Highly Aligned Muscle Tissue
Year
2018
Journal/Proceedings
Macromolecular Bioscience
Reftype
DOI/URL
DOI
Groups