SCIENTIFIC PUBLICATIONS

You are researching: Salecan
Matching entries: 3 /3
All Groups
AUTHOR Marin, Maria Minodora and Gifu, Ioana Catalina and Pircalabioru, Gratiela Gradisteanu and Albu Kaya, Madalina and Constantinescu, Rodica Roxana and Alexa, Rebeca Leu and Trica, Bogdan and Alexandrescu, Elvira and Nistor, Cristina Lavinia and Petcu, Cristian and Ianchis, Raluca
Title Microbial Polysaccharide-Based Formulation with Silica Nanoparticles; A New Hydrogel Nanocomposite for 3D Printing [Abstract]
Year 2023
Journal/Proceedings Gels
Reftype
DOI/URL URL DOI
Abstract
Natural polysaccharides are highly attractive biopolymers recommended for medical applications due to their low cytotoxicity and hydrophilicity. Polysaccharides and their derivatives are also suitable for additive manufacturing, a process in which various customized geometries of 3D structures/scaffolds can be achieved. Polysaccharide-based hydrogel materials are widely used in 3D hydrogel printing of tissue substitutes. In this context, our goal was to obtain printable hydrogel nanocomposites by adding silica nanoparticles to a microbial polysaccharide’s polymer network. Several amounts of silica nanoparticles were added to the biopolymer, and their effects on the morpho-structural characteristics of the resulting nanocomposite hydrogel inks and subsequent 3D printed constructs were studied. FTIR, TGA, and microscopy analysis were used to investigate the resulting crosslinked structures. Assessment of the swelling characteristics and mechanical stability of the nanocomposite materials in a wet state was also conducted. The salecan-based hydrogels displayed excellent biocompatibility and could be employed for biomedical purposes, according to the results of the MTT, LDH, and Live/Dead tests. The innovative, crosslinked, nanocomposite materials are recommended for use in regenerative medicine.
AUTHOR Ianchis, Raluca and Marin, Maria Minodora and Alexa, Rebeca Leu and Gifu, Ioana Catalina and Alexandrescu, Elvira and Pircalabioru, Gratiela Gradisteanu and Vlasceanu, George Mihail and Teodorescu, George Mihail and Serafim, Andrada and Preda, Silviu and Nistor, Cristina Lavinia and Petcu, Cristian
Title Nanoclay-reinforced alginate/salecan composite inks for 3D printing applications
Year 2023
Journal/Proceedings IJB
Reftype
DOI/URL DOI
AUTHOR Ianchis, Raluca and Alexa, Rebeca Leu and Gifu, Ioana Catalina and Marin, Maria Minodora and Alexandrescu, Elvira and Constantinescu, Roxana and Serafim, Andrada and Nistor, Cristina Lavinia and Petcu, Cristian
Title Novel Green Crosslinked Salecan Hydrogels and Preliminary Investigation of Their Use in 3D Printing [Abstract]
Year 2023
Journal/Proceedings Pharmaceutics
Reftype
DOI/URL URL DOI
Abstract
Salecan, a kind of polysaccharide, is produced by the Agrobacterium ZX09 salt tolerant strain. In this study, green crosslinked citric acid-salecan hydrogels are explored as novel materials with a high potential for use in regenerative medicine. The impact of salecan and citric acid on the final crosslinked hydrogels was intensively studied and estimated in terms of the whole physicochemical properties and antimicrobial activity. FTIR spectra demonstrated the successful green crosslinking of salecan through its esterification with citric acid where the formation of strong covalent bonds collaboratively helped to stabilize the entire hydrogel systems in a wet state. Hydrogels presented a microporous morphology, good swelling capacity, pH responsiveness, great mechanical stability under stress conditions and good antibacterial activity, all related to the concentration of the biopolymers used in the synthesis step. Additionally, salecan hydrogels were preliminary investigated as printing inks. Thanks to their excellent rheological behavior, we optimized the citrate-salecan hydrogel inks and printing parameters to render 3D constructs with great printing fidelity and integrity. The novel synthesized salecan green crosslinked hydrogels enriches the family of salecan-derived hydrogels. Moreover, this work not only expands the application of salecan hydrogels in various fields, but also provides a new potential option of designing salecan-based 3D printed scaffolds for customized regenerative medicine.