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You are researching: Intervertebral Disc (IVD) Tissue Engineering
Tissue and Organ Biofabrication
Skin Tissue Engineering
Drug Delivery
Biological Molecules
Solid Dosage Drugs
Stem Cells
Personalised Pharmaceuticals
Inducend Pluripotent Stem Cells (IPSCs)
Drug Discovery
Cancer Cell Lines
Cell Type
All Groups
- Review Paper
- Printing Technology
- Biomaterial
- Non-cellularized gels/pastes
- Carbopol
- Epoxy
- Poly(itaconate-co-citrate-cooctanediol) (PICO)
- poly (ethylene-co -vinyl acetate) (PEVA)
- Mineral Oil
- poly(octanediol-co-maleic anhydride-co-citrate) (POMaC)
- Poly(N-isopropylacrylamide) (PNIPAAm)
- Poly(Oxazoline)
- 2-hydroxyethyl) methacrylate (HEMA)
- Zein
- Poly(trimethylene carbonate)
- Paraffin
- Pluronic – Poloxamer
- Polyisobutylene
- Polyphenylene Oxide
- Ionic Liquids
- Silicone
- Konjac Gum
- Polyvinylpyrrolidone (PVP)
- Gelatin-Sucrose Matrix
- Salt-based
- Chlorella Microalgae
- Acrylates
- Poly(Vinyl Formal)
- 2-hydroxyethyl-methacrylate (HEMA)
- Phenylacetylene
- Salecan
- Magnetorheological fluid (MR fluid – MRF)
- Poly(vinyl alcohol) (PVA)
- Jeffamine
- PEDOT
- Polyethylene
- Micro/nano-particles
- Biological Molecules
- Bioinks
- Methacrylated hyaluronic acid (HAMA)
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- Decellularized Extracellular Matrix (dECM)
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- Non-cellularized gels/pastes
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- Bioprinting Applications
- Cell Type
- Endothelial
- CardioMyocites
- Melanocytes
- Retinal
- Corneal Stromal Cells
- Chondrocytes
- Embrionic Kidney (HEK)
- Fibroblasts
- β cells
- Myoblasts
- Pericytes
- Cancer Cell Lines
- Bacteria
- Articular cartilage progenitor cells (ACPCs)
- Tenocytes
- Monocytes
- Mesothelial cells
- Osteoblasts
- Neutrophils
- Adipocytes
- Epithelial
- Organoids
- Human Umbilical Vein Endothelial Cells (HUVECs)
- Meniscus Cells
- Synoviocytes
- Stem Cells
- Spheroids
- Skeletal Muscle-Derived Cells (SkMDCs)
- Keratinocytes
- Macrophages
- Human Trabecular Meshwork Cells
- Neurons
- Institution
- Hong Kong University
- University of Barcelona
- University of Manchester
- University of Bucharest
- Royal Free Hospital
- Rice University
- University of Nottingham
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- Hefei University
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- Adolphe Merkle Institute Fribourg
- Halle-Wittenberg University
- Baylor College of Medicine
- Tiangong University
- Zurich University of Applied Sciences (ZHAW)
- Innotere
- L'Oreal
- Innsbruck University
- ETH Zurich
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- Nanjing Medical University
- University of Bordeaux
- Politecnico di Torino
- Nanyang Technological University
- National Institutes of Health (NIH)
- Ningbo Institute of Materials Technology and Engineering (NIMTE)
- KU Leuven
- Utrecht Medical Center (UMC)
- Rizzoli Orthopaedic Institute
- Queen Mary University
- Veterans Administration Medical Center
- Biomaterials & Bioinks
- Application
- Tissue Models – Drug Discovery
- Biomaterial Processing
- Drug Discovery
- Electronics – Robotics – Industrial
- Tissue and Organ Biofabrication
- Nerve – Neural Tissue Engineering
- Meniscus Tissue Engineering
- Heart – Cardiac Patches Tissue Engineering
- Adipose Tissue Engineering
- Trachea Tissue Engineering
- Ocular Tissue Engineering
- Muscle Tissue Engineering
- Intervertebral Disc (IVD) Tissue Engineering
- Cartilage Tissue Engineering
- Bone Tissue Engineering
- Drug Delivery
- Skin Tissue Engineering
- Vascularization
- BioSensors
- Personalised Pharmaceuticals
AUTHOR
Year
2018
Journal/Proceedings
Advanced Materials
Reftype
DOI/URL
DOI
Groups
AbstractAbstract Mechanical gradients are useful to reduce strain mismatches in heterogeneous materials and thus prevent premature failure of devices in a wide range of applications. While complex graded designs are a hallmark of biological materials, gradients in manmade materials are often limited to 1D profiles due to the lack of adequate fabrication tools. Here, a multimaterial 3D‐printing platform is developed to fabricate elastomer gradients spanning three orders of magnitude in elastic modulus and used to investigate the role of various bioinspired gradient designs on the local and global mechanical behavior of synthetic materials. The digital image correlation data and finite element modeling indicate that gradients can be effectively used to manipulate the stress state and thus circumvent the weakening effect of defect‐rich interfaces or program the failure behavior of heterogeneous materials. Implementing this concept in materials with bioinspired designs can potentially lead to defect‐tolerant structures and to materials whose tunable failure facilitates repair of biomedical implants, stretchable electronics, or soft robotics.