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NEWS | EVENTS
21.01.2019 - 21.01.2019
University of Michigan
Join us January 21, 2019 in Michigan for the first 3D Bioprinting Symposium in Dentistry.
In collaboration with the School of Dentistry at the University of Michigan, regenHU organizes a first Symposium on 3D bioprinting of hard & soft engineered tissues for dentistry.
© Photo: School of Dentistry, University of Michigan
– BIOFACTORY™Read more
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– BioCUT™Read more
3D cell culture at Curio Biotech mimicks in vivo conditions.
Curio Biotech is a start-up CRO company providing services to clients ln the lite sciences sector of the pharma, cosmetlc, nutraceutlcal and diagnostic industries.
Curio Biotech constantly improves existing 30 cell culture systems and further develops novel in vitro models.
These novel 30 cell cultures can be used not only for in vitro drug discovery, screening of compounds and pre-clinlcal investigation, but can also be translated for various clinical applications.
In our ageing society, there is a huge medical need for therapies against degenerative muscle and tendon diseases. This study by researchers from ZHAW and Novartis Institutes for Biomedical Research describes a novel drug screening platform with automated production of 3D musculoskeletal-tendon-like tissues, representing a promising tool to address musculoskeletal diseases. Cells and bioink were printed using the 3DDiscovery™ bioprinter, in dumbbell lines designed by regenHU’s integrated BioCAD™ program.
Abstract: Two-dimensional (2D) cell cultures do not reflect the in vivo situation, and thus it is important to develop predictive three-dimensional (3D) in vitro models with enhanced reliability and robustness for drug screening applications. Treatments against muscle-related diseases are becoming more prominent due to the growth of the aging population worldwide. In this study, we describe a novel drug screening platform with automated production of 3D musculoskeletal-tendon-like tissues. With 3D bioprinting, alternating layers of photo-polymerized gelatin-methacryloyl-based bioink and cell suspension tissue models were produced in a dumbbell shape onto novel postholder cell culture inserts in 24-well plates. Monocultures of human primary skeletal muscle cells and rat tenocytes were printed around and between the posts. The cells showed high viability in culture and good tissue differentiation, based on marker gene and protein expressions. Different printing patterns of bioink and cells were explored and calcium signaling with Fluo4-loaded cells while electrically stimulated was shown. Finally, controlled co-printing of tenocytes and myoblasts around and between the posts, respectively, was demonstrated followed by co-culture and co-differentiation. This screening platform combining 3D bioprinting with a novel microplate represents a promising tool to address musculoskeletal diseases.Read all the article