regenHU provides cutting-edge bioprinting solutions to enable your scientific & clinical ambitions.

Scientific Publications    Partners Achievements

NEWS | EVENTS

Events
26.08.2019 - 27.08.2019
Cité des Congrès de Nantes, France, Stand #9

TERMIS-EU WORKSHOP 3D BIOPRINTING IN CANCER RESEARCH

regenHU will be a major sponsor at TERMIS-EU WORKSHOP 3D BIOPRINTING IN CANCER RESEARCH. 

Discover our latest bioprinting innovations at our stand #9 and during the session V. 

Join one of our hands-on sessions "Modelling simple and complex 3D constructs with digital assistance" and discover how our advanced software tools allow you to turn your ideas into living constructs

Scientific sessions will cover all aspects of 3D BIOPRINTING IN CANCER RESEARCH.

Discover the program.

Registration link

More info on TERMIS website.

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Partners achievements
08.05.2019
Walliser Bote Zeitung

Die Curio Biotech SA in Visp bietet eine Alternative für Kosmetik- und Medikamententests

"Die Curio Biotech SA in Visp testet Kosmetikprodukte oder Medikamente im Labor an menschlichen Zellkulturen. Mit solchen Prozedere lassen sich viele Tierversuche vermeiden. Ein weiterer Vorteil: Es kann für Menschen gar aussagekräftigere Resultate liefern."

copyright: Walliser Bote  / Fotos WB/ANDREA SOLTERMANN

Steriler Arbeitsplatz. Dr. Chennakesava Cuddapah achtet auf eine sterile Arbeitsumgebung. Die In-vitro-Modelle und Zellkulturen dürfen nicht verunreinigt werden.

Lesen das komplet Artikel.

source : Walliser Bote Zeitung

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News
13.06.2019
3DPRINT.COM

European Bioprinting Company regenHU is Paving the Way in Therapeutical Bioprinting

source: 3DPRINT.COMArticle direct link | author: by Vanesa Listek 

regenHU bioprinter at work 

Nestled in the Fribourg countryside, amid medieval towns, deep mountain lakes, and Swiss-alpine traditions, bioprinting company regenHU (which stands for regeneration human) is developing some of the most advanced 3D printers in Europe and creating alliances with research institutions that are quickly making it a leader in this emerging field. Recent advances have given them the tools for fabrication of biomimetic tissue constructs, tissue growth technologies, and drug discovery. Just over a mont...

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BIOPRINTING SOLUTIONS

3D BIOPRINTERS

– 3DDISCOVERY™

– 3DDISCOVERY™ EVOLUTION

– BIOFACTORY™

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BIOMATERIALS

– ECM BIOINK™

– OSTEOINK™

– STARK™

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BIOPRINTING SOFTWARE

– BioCAM™

– BioCAD™

– BioCUT™

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PARTNERS ACHIEVEMENTS

Die Curio Biotech SA in Visp bietet eine Alternative für Kosmetik- und Medikamententests

"Die Curio Biotech SA in Visp testet Kosmetikprodukte oder Medikamente im Labor an menschlichen Zellkulturen. Mit solchen Prozedere lassen sich viele Tierversuche vermeiden. Ein weiterer Vorteil: Es kann für Menschen gar aussagekräftigere Resultate liefern."

copyright: Walliser Bote  / Fotos WB/ANDREA SOLTERMANN

Steriler Arbeitsplatz. Dr. Chennakesava Cuddapah achtet auf eine sterile Arbeitsumgebung. Die In-vitro-Modelle und Zellkulturen dürfen nicht verunreinigt werden.

Lesen das komplet Artikel.

source : Walliser Bote Zeitung

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3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts

Once again, the flexibility of our technologies is showcased. 3DDiscovery™ Evolution was adapted to FRESH 3D Bioprinting to build vascularized and perfusable cardiac patches.


ABSTRACT : "Generation of thick vascularized tissues that fully match the patient still remains an unmet challenge in cardiac tissue engineering. Here, a simple approach to 3D‐print thick, vascularized, and perfusable cardiac patches that completely match the immunological, cellular, biochemical, and anatomical properties of the patient is reported. To this end, a biopsy of an omental tissue is taken from patients....

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A Stimuli-Responsive Nanocomposite for 3D Anisotropic Cell-Guidance and Magnetic Soft Robotics

"A novel method is presented to biofabricate anisotropic nanocomposite  hydrogels through a mild and biocompatible process driven by multiple  external stimuli: magnetic field, temperature, and light. The  functionality of this stimuliresponsive hydrogel is studied creating i)  3D cell-instructive platforms for in vitro morphogenesis, and ii) a 3D  printable magnetoresponsive ink for fabricating small-scale bioinspired soft robots"

source : Advandced Science News

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SCIENTIFIC PUBLICATIONS

Optimization of electrospray fabrication of stem cell–embedded alginate–gelatin microspheres and their assembly in 3D-printed poly(ε-caprolactone) scaffold for cartilage tissue engineering

Author: Yichi Xu and Jiang Peng and Geoff Richards and Shibi Lu and David Eglin

Abstract: Objective Our study reports the optimization of electrospray human bone marrow stromal cell (hBMSCs)–embedded alginate–gelatin (Alg-Gel, same as following) microspheres for the purpose of their assembly in 3D-printed poly(ε-caprolactone) (PCL) scaffold for the fabrication of a mechanically stable and biological supportive tissue engineering cartilage construct. Methods The fabrication of the Alg-Gel microspheres using an electrospray technique was optimized in terms of polydispersity, yield of microspheres and circularity and varying fabrication conditions. PCL scaffolds were designed and printed by melt extrusion. Then, four groups were set: Alg-hBMSC microspheres cultured in the 2D well plate (Alg-hBMSCs+2D) group, Alg-Gel-hBMSC microspheres cultured in the 2D well plate (Alg-Gel-hBMSCs+2D) group, Alg-Gel-hBMSC microspheres embedded in PCL scaffold cultured in the 2D well plate (Alg-Gel-hBMSCs+2D) group and Alg-Gel-hBMSCs microspheres cultured in the 3D bioreactor (Alg-Gel-hBMSCs+3D) group. Cell viability, proliferation and chondrogenic differentiation were evaluated, and mechanical test was performed. Results Nonaggregated, low polydispersity and almost spherical microspheres of average diameter of 200–300 μm were produced with alginate 1.5 w: v%, gelatin (Type B) concentration of 0.5 w: v % and CaCl2 coagulating bath concentration of 3.0 w: v %, using 30G needle size and 8 kV and 0.6 bar voltage and air pressure, respectively. Alginate with gelatin hydrogel improved viability and promoted hBMSC proliferation better than alginate microspheres. Interestingly, hBMSCs embedded in microspheres assembled in 3D-printed PCL scaffold and cultured in a 3D bioreactor were more proliferative in comparison to the previous two groups (p < 0.05). Similarly, the GAG content, GAG/DNA ratio as well as Coll 2 and Aggr gene expression were increased in the last two groups. Conclusion Optimization of hBMSC-embedded Alg-Gel microspheres produced by electrospray has been performed. The Alg-Gel composition selected allows conservation of hBMSC viability and supports proliferation and matrix deposition. The possibility to seed and assemble microspheres in designed 3D-printed PCL scaffolds for the fabrication of a mechanically stable and biological supportive tissue engineering cartilage construct was demonstrated. Translational potential of this article We optimize and demonstrate that electrospray microsphere fabrication is a cytocompatible and facile process to produce the hBMSC-embedded microsize tissue-like particles that can easily be assembled into a stable construct. This finding could have application in the development of mechanically competent stem cell–based tissue engineering of cartilage regeneration.

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