Shaping the future of healthcare together!

Since 2007, regenHU has dedicated its engineering skills to assist the scientific community with cutting-edge 3D bioprinting solutions.

regenHU’s bioprinters offer a wide selection of high-end professional bioprinting instruments for the driving force of scientific advancements in Tissue Engineering, Regenerative Medicine and Drug Discovery.

Discover ~200 scientific publications using regenHU bioprinters

NEWS | EVENTS

Events
24.10.2019 - 24.10.2019
Zurich University of Applied Science, Switzerland

TEDD Annual Meeting 2019

This year’s TEDD Annual Meeting brings together experts from diverse fields with a shared interest in advanced 3D models. Join us for this meeting to celebrate another fruitful collaboration year with the new perspectives ahead. 


Program

Registration

More information on zhaw website.

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Partners achievements
12.06.2019
Nanyang Technological University Singapore

Layer-by-layer ultraviolet assisted extrusion-based (UAE) bioprinting of hydrogel constructs with high aspect ratio for soft tissue engineering applications

Using the 3DDiscovery’s layer-by-layer UV curing system, researchers at NTU Singapore built thick cell-laden constructs with high shape fidelity and mechanical properties suitable for soft tissue engineering applications.

Sources :
https://doi.org/10.1371/journal.pone.0216776
Authors: Pei Zhuang, Wei Long Ng, Jia An, Chee Kai Chua, Lay Poh Tan

Abstract

One of the major challenges in the field of soft tissue engineering using bioprinting is fabricating complex tissue constructs with desired structure integrity and mechanical property. To accomplish such requirements, most of the r...


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News
03.07.2019
3DPRINT.COM, by Sarah Saunders

Singapore: UV-Assisted Extrusion-Based Bioprinting to Make GelMA Hydrogels for Soft Tissue Engineering

"It’s difficult to manufacture complex tissue constructs with the necessary mechanical properties and structure integrity when you’re with bioprinting in soft tissue engineering. Typically, scientists will use materials, like PCL, to reinforce the inside of 3D bioprinting constructs, but the long degradation period is not great. But a team of researchers – Pei Zhuang, Wei Long Ng, Jia An, Chee Kai Chua, and Lay Poh Tan – from Singapore’s Nanyang Technological University have proposed a novel UV-assisted, extrusion-based (UAE) 3D bioprinting method that could help fabricate soft tissue construc...

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BIOPRINTING SOLUTIONS

3D BIOPRINTERS

– 3DDISCOVERY™ EVOLUTION

– BIOFACTORY™

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BIOMATERIALS

– ECM BIOINK™

– OSTEOINK™

– STARK™

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BIOPRINTING SOFTWARE

– BioCAM™

– BioCAD™

– BioCUT™

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PARTNERS ACHIEVEMENTS

Layer-by-layer ultraviolet assisted extrusion-based (UAE) bioprinting of hydrogel constructs with high aspect ratio for soft tissue engineering applications

Using the 3DDiscovery’s layer-by-layer UV curing system, researchers at NTU Singapore built thick cell-laden constructs with high shape fidelity and mechanical properties suitable for soft tissue engineering applications.

Sources :
https://doi.org/10.1371/journal.pone.0216776
Authors: Pei Zhuang, Wei Long Ng, Jia An, Chee Kai Chua, Lay Poh Tan

Abstract

One of the major challenges in the field of soft tissue engineering using bioprinting is fabricating complex tissue constructs with desired structure integrity and mechanical property. To accomplish such requirements, most of the r...


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3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts

Once again, the flexibility of our technologies is showcased. 3DDiscovery™ Evolution was adapted to FRESH 3D Bioprinting to build vascularized and perfusable cardiac patches.


ABSTRACT : "Generation of thick vascularized tissues that fully match the patient still remains an unmet challenge in cardiac tissue engineering. Here, a simple approach to 3D‐print thick, vascularized, and perfusable cardiac patches that completely match the immunological, cellular, biochemical, and anatomical properties of the patient is reported. To this end, a biopsy of an omental tissue is taken from patients....

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A Stimuli-Responsive Nanocomposite for 3D Anisotropic Cell-Guidance and Magnetic Soft Robotics

"A novel method is presented to biofabricate anisotropic nanocomposite  hydrogels through a mild and biocompatible process driven by multiple  external stimuli: magnetic field, temperature, and light. The  functionality of this stimuliresponsive hydrogel is studied creating i)  3D cell-instructive platforms for in vitro morphogenesis, and ii) a 3D  printable magnetoresponsive ink for fabricating small-scale bioinspired soft robots"

source : Advandced Science News

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SCIENTIFIC PUBLICATIONS

Optimization of electrospray fabrication of stem cell–embedded alginate–gelatin microspheres and their assembly in 3D-printed poly(ε-caprolactone) scaffold for cartilage tissue engineering

Author: Yichi Xu and Jiang Peng and Geoff Richards and Shibi Lu and David Eglin

Abstract: Objective Our study reports the optimization of electrospray human bone marrow stromal cell (hBMSCs)–embedded alginate–gelatin (Alg-Gel, same as following) microspheres for the purpose of their assembly in 3D-printed poly(ε-caprolactone) (PCL) scaffold for the fabrication of a mechanically stable and biological supportive tissue engineering cartilage construct. Methods The fabrication of the Alg-Gel microspheres using an electrospray technique was optimized in terms of polydispersity, yield of microspheres and circularity and varying fabrication conditions. PCL scaffolds were designed and printed by melt extrusion. Then, four groups were set: Alg-hBMSC microspheres cultured in the 2D well plate (Alg-hBMSCs+2D) group, Alg-Gel-hBMSC microspheres cultured in the 2D well plate (Alg-Gel-hBMSCs+2D) group, Alg-Gel-hBMSC microspheres embedded in PCL scaffold cultured in the 2D well plate (Alg-Gel-hBMSCs+2D) group and Alg-Gel-hBMSCs microspheres cultured in the 3D bioreactor (Alg-Gel-hBMSCs+3D) group. Cell viability, proliferation and chondrogenic differentiation were evaluated, and mechanical test was performed. Results Nonaggregated, low polydispersity and almost spherical microspheres of average diameter of 200–300 μm were produced with alginate 1.5 w: v%, gelatin (Type B) concentration of 0.5 w: v % and CaCl2 coagulating bath concentration of 3.0 w: v %, using 30G needle size and 8 kV and 0.6 bar voltage and air pressure, respectively. Alginate with gelatin hydrogel improved viability and promoted hBMSC proliferation better than alginate microspheres. Interestingly, hBMSCs embedded in microspheres assembled in 3D-printed PCL scaffold and cultured in a 3D bioreactor were more proliferative in comparison to the previous two groups (p < 0.05). Similarly, the GAG content, GAG/DNA ratio as well as Coll 2 and Aggr gene expression were increased in the last two groups. Conclusion Optimization of hBMSC-embedded Alg-Gel microspheres produced by electrospray has been performed. The Alg-Gel composition selected allows conservation of hBMSC viability and supports proliferation and matrix deposition. The possibility to seed and assemble microspheres in designed 3D-printed PCL scaffolds for the fabrication of a mechanically stable and biological supportive tissue engineering cartilage construct was demonstrated. Translational potential of this article We optimize and demonstrate that electrospray microsphere fabrication is a cytocompatible and facile process to produce the hBMSC-embedded microsize tissue-like particles that can easily be assembled into a stable construct. This finding could have application in the development of mechanically competent stem cell–based tissue engineering of cartilage regeneration.

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