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Scientific Publications  Partners Achievements


NEWS | EVENTS

Partners achievements
15.04.2019
Tel-Aviv University

3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts

ABSTRACT : "Generation of thick vascularized tissues that fully match the patient still remains an unmet challenge in cardiac tissue engineering. Here, a simple approach to 3D‐print thick, vascularized, and perfusable cardiac patches that completely match the immunological, cellular, biochemical, and anatomical properties of the patient is reported. To this end, a biopsy of an omental tissue is taken from patients. While the cells are reprogrammed to become pluripotent stem cells, and differentiated to cardiomyocytes and endothelial cells, the extracellular matrix is processed into a personal...

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News
15.04.2019
20min.ch

Das ist das menschliche Herz aus dem 3D-Drucker

copyright 20min.ch


"Forscher in Israel haben am Montag den Prototypen eines im 3D-Drucker hergestellten Herzens aus menschlichem Gewebe vorgestellt.

Israelische Forscher haben mit einem 3D-Drucker ein Mini-Herz aus menschlichem Gewebe geschaffen. Der Prototyp, dessen Zellen sich allerdings noch nicht synchron zusammenziehen können, hat die Grösse eines Hasenherzens.

Das Herz bestehe aus Gewebe und Blutgefässen und verfüge über Kammern, sagte Studienleiter Tal Dvir von der Universität Tel Aviv am Montag vor Journalisten. Es sei vergleichbar mit dem Herz eines menschlichen Fötus. Die Forsch...



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News
15.04.2019
lematin.ch

Un coeur en 3D imprimé à partir de tissu humain

"Le prototype de coeur humain a été imprimé à partir de cellules prélevées sur le tissu du patient, ce qui réduit les risques de réaction immunitaire de l'organisme.

copyright : lematin.ch

Des scientifiques ont présenté lundi à Tel-Aviv un prototype de coeur humain imprimé en 3D à partir de tissus humains et avec des vaisseaux. Ils saluent une avancée «majeure» dans le traitement des maladies cardiovasculaires et la prévention du rejet des greffes.

Les chercheurs de l'université de Tel-Aviv ont présenté à la presse ce coeur inerte de la taille d'une cerise, plongé dans un liquide. «C'est la pr...

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BIOPRINTING SOLUTIONS

3D BIOPRINTERS

– 3DDISCOVERY™

– 3DDISCOVERY™ EVOLUTION

– BIOFACTORY™

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BIOMATERIALS

– ECM BIOINK™

– OSTEOINK™

– STARK™

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BIOPRINTING SOFTWARE

– BioCAM™

– BioCAD™

– BioCUT™

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PARTNERS ACHIEVEMENTS

3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts

ABSTRACT : "Generation of thick vascularized tissues that fully match the patient still remains an unmet challenge in cardiac tissue engineering. Here, a simple approach to 3D‐print thick, vascularized, and perfusable cardiac patches that completely match the immunological, cellular, biochemical, and anatomical properties of the patient is reported. To this end, a biopsy of an omental tissue is taken from patients. While the cells are reprogrammed to become pluripotent stem cells, and differentiated to cardiomyocytes and endothelial cells, the extracellular matrix is processed into a personal...

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A Stimuli-Responsive Nanocomposite for 3D Anisotropic Cell-Guidance and Magnetic Soft Robotics

"A novel method is presented to biofabricate anisotropic nanocomposite  hydrogels through a mild and biocompatible process driven by multiple  external stimuli: magnetic field, temperature, and light. The  functionality of this stimuliresponsive hydrogel is studied creating i)  3D cell-instructive platforms for in vitro morphogenesis, and ii) a 3D  printable magnetoresponsive ink for fabricating small-scale bioinspired soft robots"

source : Advandced Science News

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Bioprinting with Biogelx-Ink

Álvaro Sánchez Rubio, a Ph.D. researcher at the University of Glasgow, is printing with Biogelx-Ink-S.

Source: Biogelx Limited

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SCIENTIFIC PUBLICATIONS

Spatially-offset Raman spectroscopy for monitoring mineralization of bone tissue engineering scaffolds: feasibility study based on phantom samples

Author: Max Dooley and Aruna Prasopthum and Zhiyu Liao and Faris Sinjab and Jane McLaren and Felicity R. A. J. Rose and Jing Yang and Ioan Notingher

Abstract: Using phantom samples, we investigated the feasibility of spatially-offset Raman spectroscopy (SORS) as a tool for monitoring non-invasively the mineralization of bone tissue engineering scaffold in-vivo. The phantom samples consisted of 3D-printed scaffolds of poly-caprolactone (PCL) and hydroxyapatite (HA) blends, with varying concentrations of HA, to mimic the mineralisation process. The scaffolds were covered by a 4 mm layer of skin to simulate the real in-vivo measurement conditions. At a concentration of HA approximately 1/3 that of bone (~0.6 g/cm3), the characteristic Raman band of HA (960 cm\&\#x2212;1) was detectable when the PCL:HA layer was located at 4 mm depth within the scaffold (i.e. 8 mm below the skin surface). For the layers of the PCL:HA immediately under the skin (i.e. top of the scaffold), the detection limit of HA was 0.18 g/cm3, which is approximately one order of magnitude lower than that of bone. Similar results were also found for the phantoms simulating uniform and inward gradual mineralisation of the scaffold, indicating the suitability of SORS to detect early stages of mineralisation. Nevertheless, the results also show that the contribution of the materials surrounding the scaffold can be significant and methods for subtraction need to be investigated in the future. In conclusion, these results indicate that spatially-offset Raman spectroscopy is a promising technique for in-vivo longitudinal monitoring scaffold mineralization and bone re-growth.

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