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NEWS | EVENTS

Events
21.11.2018 - 23.11.2018
Gent, Belgium

Belgian Symposium on Tissue Engineering 2018

It is our great pleasure to announce the 6th Belgian Symposium on Tissue Engineering 2018, themed ‘Next generation tissue engineering’. This event will be held on November 21-23 2018, at the Oude Vismijn, Gent.


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Partners achievements
03.09.2018
Science Daily

A novel microplate 3D bioprinting platform for the engineering of muscle and tendon tissues

In our ageing society, there is a huge medical need for therapies against degenerative muscle and tendon diseases. This study by researchers from ZHAW and Novartis Institutes for  Biomedical Research describes a novel drug screening platform with  automated production of 3D musculoskeletal-tendon-like tissues,  representing a promising tool to address musculoskeletal diseases. Cells and bioink were printed using the 3DDiscovery™ bioprinter, in  dumbbell lines designed by regenHU’s integrated BioCAD™ program.

www.sciencedaily.com

Scientific publication

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News
10.09.2018
20 Minuten

Organe aus dem 3D-Drucker könnten Leben retten

Organversagen ist lebensbedrohlich, doch Spenderorgane sind rar. Deshalb wollen Mediziner Organe im Labor herstellen –zum Beispiel mittels 3D-Drucker. (Life-Sciences-Woche, Teil 1/5)

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APPLICATIONS

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PARTNERS ACHIEVEMENTS

A novel microplate 3D bioprinting platform for the engineering of muscle and tendon tissues

In our ageing society, there is a huge medical need for therapies against degenerative muscle and tendon diseases. This study by researchers from ZHAW and Novartis Institutes for  Biomedical Research describes a novel drug screening platform with  automated production of 3D musculoskeletal-tendon-like tissues,  representing a promising tool to address musculoskeletal diseases. Cells and bioink were printed using the 3DDiscovery™ bioprinter, in  dumbbell lines designed by regenHU’s integrated BioCAD™ program.

www.sciencedaily.com

Scientific publication

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The US Dominates the ARWU’s Best Dental Schools for 2018

Zeynep Aytac works with a 3D-Discovery Bioprinter at the University of Michigan School of Dentistry.

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SCIENTIFIC PUBLICATIONS

A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues

Author: Sandra Laternser and Hansjoerg Keller and Olivier Leupin and Martin Rausch and Ursula Graf-Hausner and Markus Rimann

Abstract: Two-dimensional (2D) cell cultures do not reflect the in vivo situation, and thus it is important to develop predictive three-dimensional (3D) in vitro models with enhanced reliability and robustness for drug screening applications. Treatments against muscle-related diseases are becoming more prominent due to the growth of the aging population worldwide. In this study, we describe a novel drug screening platform with automated production of 3D musculoskeletal-tendon-like tissues. With 3D bioprinting, alternating layers of photo-polymerized gelatin-methacryloyl-based bioink and cell suspension tissue models were produced in a dumbbell shape onto novel postholder cell culture inserts in 24-well plates. Monocultures of human primary skeletal muscle cells and rat tenocytes were printed around and between the posts. The cells showed high viability in culture and good tissue differentiation, based on marker gene and protein expressions. Different printing patterns of bioink and cells were explored and calcium signaling with Fluo4-loaded cells while electrically stimulated was shown. Finally, controlled co-printing of tenocytes and myoblasts around and between the posts, respectively, was demonstrated followed by co-culture and co-differentiation. This screening platform combining 3D bioprinting with a novel microplate represents a promising tool to address musculoskeletal diseases.

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