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You are researching: Hong Kong University
Cell Type
Tissue and Organ Biofabrication
Skin Tissue Engineering
Drug Delivery
Biological Molecules
Solid Dosage Drugs
Stem Cells
Personalised Pharmaceuticals
Inducend Pluripotent Stem Cells (IPSCs)
Drug Discovery
Cancer Cell Lines
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- Organoids
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- CardioMyocites
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- β cells
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- Institution
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- Review Paper
- Printing Technology
- Biomaterial
- Thermoplastics
- Bioinks
- Xanthan Gum
- Paeoniflorin
- Alginate
- Gelatin-Methacryloyl (GelMA)
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- Glucosamine
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- Jeffamine
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- Pluronic – Poloxamer
- Silicone
- Polyvinylpyrrolidone (PVP)
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- Magnetorheological fluid (MR fluid – MRF)
- Poly(vinyl alcohol) (PVA)
- PEDOT
- Polyethylene
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- poly (ethylene-co -vinyl acetate) (PEVA)
- Poly(N-isopropylacrylamide) (PNIPAAm)
- Poly(Oxazoline)
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- Gelatin-Sucrose Matrix
- Chlorella Microalgae
- Poly(Vinyl Formal)
- Phenylacetylene
- 2-hydroxyethyl) methacrylate (HEMA)
- Paraffin
- Polyphenylene Oxide
- Micro/nano-particles
- Biological Molecules
- Decellularized Extracellular Matrix (dECM)
- Solid Dosage Drugs
- Ceramics
- Metals
AUTHOR
Title
4D printing of highly printable and shape morphing hydrogels composed of alginate and methylcellulose
[Abstract]
Year
2021
Journal/Proceedings
Materials & Design
Reftype
Groups
Abstract4D printing of swellable/shrinkable hydrogels has been viewed as an appealing approach for fabricating dynamic structures for various biomedical applications. However, 4D printing of precise hydrogel structures is still highly challenging due to the relatively poor printability of hydrogels and high surface roughness of printed patterns, when micro extrusion-based 3D printers are used. In this study, a highly printable and shape morphing hydrogel was investigated for 4D printing by blending alginate (Alg) and methylcellulose (MC). The optimized Alg/MC hydrogel exhibited excellent rheological properties, extrudability and shape fidelity of printed structures. The printable Alg/MC hydrogel was 4D printed into a series of patterned 2D architectures which were encoded with anisotropic stiffness and swelling behaviors by strategically controlling the network density gradients vertical to the orientation of the patterned strips. By controlling the strip interspacing and angle, these 2D architectures could transform into various prescribed simple 3D morphologies (e.g., tube-curling and helix) and complex 3D morphologies (e.g., double helix and flowers) after immersion in a calcium chloride solution. This shape morphing Alg/MC hydrogel with excellent printability has high potential for 4D printing of delicate hydrogel patterns, which are increasingly needed in the tissue engineering, biomedical device and soft robotics fields.