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AUTHOR Martínez-Pérez, David Martinez and Reigada, Inés and Patel, Jayendra Z and Yli-Kauhaluoma, Jari and Hanski, Leena L and Srebrzynski, Michał and Spychalski, Maciej and Choińska, Emilia and Fallarero, Adyary and Swieszkowski, Wojciech
Title Drop-on-demand antimicrobial printed coatings loaded with dehydroabietic acid derivative to prevent orthopedic implant infections [Abstract]
Year 2026
Journal/Proceedings J. Mater. Chem. B
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DOI/URL DOI
Abstract
Microvalve-based drop-on-demand (DOD) printing technology was applied to create antimicrobial coatings for orthopedic implants. Leveraging the high-precision deposition capabilities of DOD{,} coatings loaded with a novel biofilm inhibitor{,} N- (abiet-8{,}11{,}13-trien-18oyl) cyclohexyl-L-alanine (DHA1){,} were fabricated on titanium coupons. The PLGA-PEG-DHA1 coatings exhibited significant efficacy in preventing Staphylococcus aureus adhesion in monoand co-culture with HL-60 cells. Furthermore{,} the PLGA-PEG-DHA1 coatings showed a sustained protective effect of the 30% DHA1-loaded coating over 24 hours. The PLGA-PEG-DHA1 coatings ensured safety with no cytotoxic effect observed on SaOS-2 mammalian cells{,} fostering tissue integration post-implantation. This study paves the way to produce multi-component DOD coatings combining various ink compositions{,} including different polymers{,} antimicrobial agents{,} or growth factors.