BROCHURES / DOCUMENTATION
APPLICATION NOTES
SCIENTIFIC PUBLICATIONS
You are researching: Organoids
Biological Molecules
Solid Dosage Drugs
Stem Cells
Personalised Pharmaceuticals
Inducend Pluripotent Stem Cells (IPSCs)
Drug Discovery
Cancer Cell Lines
Cell Type
Tissue and Organ Biofabrication
Skin Tissue Engineering
Drug Delivery
All Groups
- Review Paper
- Printing Technology
- Biomaterial
- Non-cellularized gels/pastes
- Epoxy
- Poly(itaconate-co-citrate-cooctanediol) (PICO)
- poly (ethylene-co -vinyl acetate) (PEVA)
- Mineral Oil
- poly(octanediol-co-maleic anhydride-co-citrate) (POMaC)
- Poly(N-isopropylacrylamide) (PNIPAAm)
- Poly(Oxazoline)
- 2-hydroxyethyl) methacrylate (HEMA)
- Zein
- Acrylamide
- Poly(trimethylene carbonate)
- Paraffin
- Pluronic – Poloxamer
- Polyisobutylene
- Polyphenylene Oxide
- Ionic Liquids
- Silicone
- Konjac Gum
- Polyvinylpyrrolidone (PVP)
- Gelatin-Sucrose Matrix
- Salt-based
- Chlorella Microalgae
- Acrylates
- Poly(Vinyl Formal)
- 2-hydroxyethyl-methacrylate (HEMA)
- Phenylacetylene
- Salecan
- Magnetorheological fluid (MR fluid – MRF)
- Poly(vinyl alcohol) (PVA)
- Jeffamine
- Poly(methyl methacrylate) (PMMA)
- PEDOT
- SEBS
- Polypropylene Oxide (PPO)
- Polyethylene
- Sucrose Acetate
- Carbopol
- Micro/nano-particles
- Biological Molecules
- Bioinks
- Xanthan Gum
- Silk Fibroin
- Pyrogallol
- Paeoniflorin
- Fibronectin
- Fibrinogen
- Fibrin
- (2-Hydroxypropyl)methacrylamide (HPMA)
- Methacrylated Collagen (CollMA)
- Carrageenan
- Glucosamine
- Chitosan
- Glycerol
- Poly(glycidol)
- Alginate
- Agarose
- Gelatin-Methacryloyl (GelMA)
- methacrylated chondroitin sulfate (CSMA)
- carboxybetaine acrylamide (CBAA)
- Cellulose
- Novogel
- Methacrylated Silk Fibroin
- Pantoan Methacrylate
- Hyaluronic Acid
- Peptide gel
- Poly(Acrylic Acid)
- Polyethylene glycol (PEG) based
- α-Bioink
- Heparin
- sulfobetaine methacrylate (SBMA)
- Collagen
- Elastin
- Gelatin
- Matrigel
- Gellan Gum
- Methacrylated Chitosan
- Methacrylated hyaluronic acid (HAMA)
- Pectin
- Ceramics
- Metals
- Decellularized Extracellular Matrix (dECM)
- Solid Dosage Drugs
- Thermoplastics
- Coaxial Extruder
- Non-cellularized gels/pastes
- Bioprinting Technologies
- Bioprinting Applications
- Cell Type
- CardioMyocites
- Melanocytes
- Retinal
- Corneal Stromal Cells
- Annulus Fibrosus Cells
- Chondrocytes
- Embrionic Kidney (HEK)
- Astrocytes
- Fibroblasts
- β cells
- Hepatocytes
- Myoblasts
- Pericytes
- Epicardial Cells
- Cancer Cell Lines
- Bacteria
- Extracellular Vesicles
- Articular cartilage progenitor cells (ACPCs)
- Tenocytes
- Monocytes
- Mesothelial cells
- Nucleus Pulposus Cells
- Osteoblasts
- Neutrophils
- Adipocytes
- Smooth Muscle Cells
- Epithelial
- T cells
- Organoids
- Human Umbilical Vein Endothelial Cells (HUVECs)
- Meniscus Cells
- Synoviocytes
- Stem Cells
- Spheroids
- Skeletal Muscle-Derived Cells (SkMDCs)
- Keratinocytes
- Macrophages
- Human Trabecular Meshwork Cells
- Neurons
- Endothelial
- Institution
- SINTEF
- Rice University
- Jiangsu University
- University of Nottingham
- University of Geneva
- University of Central Florida
- Hefei University
- Leibniz University Hannover
- Trinity College
- Novartis
- University of Freiburg
- Helmholtz Institute for Pharmaceutical Research Saarland
- Leipzig University
- Chalmers University of Technology
- Karlsruhe institute of technology
- Univerity of Hong Kong
- University of Toronto
- Brown University
- Polish Academy of Sciences
- AO Research Institute (ARI)
- Shanghai University
- University of Nantes
- Montreal University
- Shandong Medical University
- University of Wurzburg
- Technical University of Dresden
- Myiongji University
- Harbin Institute of Technology
- Technical University of Berlin
- Institute for Bioengineering of Catalonia (IBEC)
- University of Michigan – School of Dentistry
- University of Applied Sciences Northwestern Switzerland
- Anhui Polytechnic
- University Children's Hospital Zurich
- University of Amsterdam
- University of Tel Aviv
- University of Michigan, Biointerfaces Institute
- Abu Dhabi University
- Jiao Tong University
- University of Aveiro
- Bayreuth University
- Aschaffenburg University
- Sree Chitra Tirunal Institute
- University of Sheffield
- University of Michigan – Biointerfaces Institute
- Ghent University
- Chiao Tung University
- Kaohsiung Medical University
- DTU – Technical University of Denmark
- University of Taiwan
- National University of Singapore
- CIC biomaGUNE
- Baylor College of Medicine
- INM – Leibniz Institute for New Materials
- National Yang Ming Chiao Tung University
- University of Vilnius
- Adolphe Merkle Institute Fribourg
- Halle-Wittenberg University
- L'Oreal
- Tiangong University
- Xi’an Children’s Hospital
- Zurich University of Applied Sciences (ZHAW)
- Innotere
- University of Bordeaux
- Innsbruck University
- DWI – Leibniz Institute
- ETH Zurich
- Hallym University
- Nanjing Medical University
- KU Leuven
- Politecnico di Torino
- Nanyang Technological University
- National Institutes of Health (NIH)
- Ningbo Institute of Materials Technology and Engineering (NIMTE)
- Veterans Administration Medical Center
- Utrecht Medical Center (UMC)
- Rizzoli Orthopaedic Institute
- Queen Mary University
- Hong Kong University
- University of Barcelona
- Chinese Academy of Sciences
- ENEA
- University of Manchester
- University of Bucharest
- Royal Free Hospital
- Biomaterials & Bioinks
- Application
- Bioelectronics
- Tissue Models – Drug Discovery
- Industrial
- Biomaterial Processing
- In Vitro Models
- Robotics
- Drug Discovery
- Medical Devices
- Electronics – Robotics – Industrial
- Tissue and Organ Biofabrication
- Meniscus Tissue Engineering
- Heart – Cardiac Patches Tissue Engineering
- Adipose Tissue Engineering
- Trachea Tissue Engineering
- Ocular Tissue Engineering
- Muscle Tissue Engineering
- Intervertebral Disc (IVD) Tissue Engineering
- Liver tissue Engineering
- Cartilage Tissue Engineering
- Dental Tissue Engineering
- Bone Tissue Engineering
- Urethra Tissue Engineering
- Drug Delivery
- Uterus Tissue Engineering
- Skin Tissue Engineering
- Nerve – Neural Tissue Engineering
- BioSensors
- Personalised Pharmaceuticals
AUTHOR
Year
2021
Journal/Proceedings
Macromolecular Bioscience
Reftype
DOI/URL
DOI
Groups
AbstractAbstract There is a need for long-lived hepatic in vitro models to better predict drug induced liver injury (DILI). Human liver-derived epithelial organoids are a promising cell source for advanced in vitro models. Here, organoid technology is combined with biofabrication techniques, which holds great potential for the design of in vitro models with complex and customizable architectures. Here, porous constructs with human hepatocyte-like cells derived from organoids are generated using extrusion-based printing technology. Cell viability of bioprinted organoids remains stable for up to ten days (88–107% cell viability compared to the day of printing). The expression of hepatic markers, transporters, and phase I enzymes increased compared to undifferentiated controls, and is comparable to non-printed controls. Exposure to acetaminophen, a well-known hepatotoxic compound, decreases cell viability of bioprinted liver organoids to 21–51% (p < 0.05) compared to the start of exposure, and elevated levels of damage marker miR-122 are observed in the culture medium, indicating the potential use of the bioprinted constructs for toxicity testing. In conclusion, human liver-derived epithelial organoids can be combined with a biofabrication approach, thereby paving the way to create perfusable, complex constructs which can be used as toxicology- and disease-models.
AUTHOR
Year
2023
Journal/Proceedings
Expert Opinion on Drug Discovery
Reftype
DOI/URL
DOI
AbstractABSTRACTIntroduction 3D printing, a versatile additive manufacturing technique, has diverse applications ranging from transportation, rapid prototyping, clean energy, and medical devices.Areas covered The authors focus on how 3D printing technology can enhance the drug discovery process through automating tissue production that enables high-throughput screening of potential drug candidates. They also discuss how the 3D bioprinting process works and what considerations to address when using this technology to generate cell laden constructs for drug screening as well as the outputs from such assays necessary for determining the efficacy of potential drug candidates. They focus on how bioprinting how has been used to generate cardiac, neural, and testis tissue models, focusing on bio-printed 3D organoids.Expert opinion The next generation of 3D bioprinted organ model holds great promises for the field of medicine. In terms of drug discovery, the incorporation of smart cell culture systems and biosensors into 3D bioprinted models could provide highly detailed and functional organ models for drug screening. By addressing current challenges of vascularization, electrophysiological control, and scalability, researchers can obtain more reliable and accurate data for drug development, reducing the risk of drug failures during clinical trials.