BROCHURES / DOCUMENTATION
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SCIENTIFIC PUBLICATIONS
You are researching: Material Mixer
Cell Type
Tissue and Organ Biofabrication
Skin Tissue Engineering
Drug Delivery
Biological Molecules
Solid Dosage Drugs
Stem Cells
Personalised Pharmaceuticals
Inducend Pluripotent Stem Cells (IPSCs)
Drug Discovery
Cancer Cell Lines
All Groups
- Cell Type
- Organoids
- Human Umbilical Vein Endothelial Cells (HUVECs)
- Meniscus Cells
- Synoviocytes
- Stem Cells
- Spheroids
- Skeletal Muscle-Derived Cells (SkMDCs)
- Keratinocytes
- Macrophages
- Human Trabecular Meshwork Cells
- Neurons
- Endothelial
- CardioMyocites
- Melanocytes
- Retinal
- Corneal Stromal Cells
- Annulus Fibrosus Cells
- Chondrocytes
- Embrionic Kidney (HEK)
- Astrocytes
- Fibroblasts
- β cells
- Hepatocytes
- Myoblasts
- Pericytes
- Epicardial Cells
- Cancer Cell Lines
- Bacteria
- Extracellular Vesicles
- Articular cartilage progenitor cells (ACPCs)
- Tenocytes
- Monocytes
- Mesothelial cells
- Nucleus Pulposus Cells
- Osteoblasts
- Neutrophils
- Adipocytes
- Smooth Muscle Cells
- Epithelial
- T cells
- Institution
- L'Oreal
- Tiangong University
- Xi’an Children’s Hospital
- Zurich University of Applied Sciences (ZHAW)
- Innotere
- University of Bordeaux
- Innsbruck University
- DWI – Leibniz Institute
- ETH Zurich
- Hallym University
- Nanjing Medical University
- KU Leuven
- Politecnico di Torino
- Nanyang Technological University
- National Institutes of Health (NIH)
- Ningbo Institute of Materials Technology and Engineering (NIMTE)
- Veterans Administration Medical Center
- Utrecht Medical Center (UMC)
- Rizzoli Orthopaedic Institute
- Queen Mary University
- Hong Kong University
- University of Barcelona
- Chinese Academy of Sciences
- ENEA
- University of Manchester
- University of Bucharest
- Royal Free Hospital
- Rice University
- Jiangsu University
- University of Nottingham
- University of Geneva
- SINTEF
- Hefei University
- Leibniz University Hannover
- Trinity College
- Novartis
- University of Central Florida
- Helmholtz Institute for Pharmaceutical Research Saarland
- Leipzig University
- Chalmers University of Technology
- Karlsruhe institute of technology
- University of Freiburg
- University of Toronto
- Brown University
- Polish Academy of Sciences
- AO Research Institute (ARI)
- Shanghai University
- Univerity of Hong Kong
- Montreal University
- Shandong Medical University
- University of Wurzburg
- Technical University of Dresden
- University of Nantes
- Harbin Institute of Technology
- Technical University of Berlin
- Institute for Bioengineering of Catalonia (IBEC)
- University of Michigan – School of Dentistry
- Myiongji University
- Anhui Polytechnic
- University Children's Hospital Zurich
- University of Amsterdam
- University of Tel Aviv
- University of Applied Sciences Northwestern Switzerland
- Abu Dhabi University
- Jiao Tong University
- University of Aveiro
- Bayreuth University
- Aschaffenburg University
- University of Michigan, Biointerfaces Institute
- University of Sheffield
- University of Michigan – Biointerfaces Institute
- Ghent University
- Chiao Tung University
- Sree Chitra Tirunal Institute
- DTU – Technical University of Denmark
- University of Taiwan
- National University of Singapore
- CIC biomaGUNE
- Kaohsiung Medical University
- INM – Leibniz Institute for New Materials
- National Yang Ming Chiao Tung University
- University of Vilnius
- Adolphe Merkle Institute Fribourg
- Halle-Wittenberg University
- Baylor College of Medicine
- Biomaterials & Bioinks
- Application
- Bioelectronics
- Tissue Models – Drug Discovery
- Industrial
- Biomaterial Processing
- In Vitro Models
- Robotics
- Drug Discovery
- Medical Devices
- Electronics – Robotics – Industrial
- Tissue and Organ Biofabrication
- Dental Tissue Engineering
- Bone Tissue Engineering
- Urethra Tissue Engineering
- Drug Delivery
- Uterus Tissue Engineering
- Skin Tissue Engineering
- Nerve – Neural Tissue Engineering
- Meniscus Tissue Engineering
- Heart – Cardiac Patches Tissue Engineering
- Adipose Tissue Engineering
- Trachea Tissue Engineering
- Ocular Tissue Engineering
- Muscle Tissue Engineering
- Intervertebral Disc (IVD) Tissue Engineering
- Liver tissue Engineering
- Cartilage Tissue Engineering
- BioSensors
- Personalised Pharmaceuticals
- Review Paper
- Printing Technology
- Biomaterial
- Thermoplastics
- Coaxial Extruder
- Non-cellularized gels/pastes
- Salecan
- Magnetorheological fluid (MR fluid – MRF)
- Poly(vinyl alcohol) (PVA)
- Jeffamine
- Poly(methyl methacrylate) (PMMA)
- PEDOT
- SEBS
- Polypropylene Oxide (PPO)
- Polyethylene
- Sucrose Acetate
- Carbopol
- Epoxy
- Poly(itaconate-co-citrate-cooctanediol) (PICO)
- poly (ethylene-co -vinyl acetate) (PEVA)
- Mineral Oil
- poly(octanediol-co-maleic anhydride-co-citrate) (POMaC)
- Poly(N-isopropylacrylamide) (PNIPAAm)
- Poly(Oxazoline)
- 2-hydroxyethyl) methacrylate (HEMA)
- Zein
- Acrylamide
- Poly(trimethylene carbonate)
- Paraffin
- Pluronic – Poloxamer
- Polyisobutylene
- Polyphenylene Oxide
- Ionic Liquids
- Silicone
- Konjac Gum
- Polyvinylpyrrolidone (PVP)
- Gelatin-Sucrose Matrix
- Salt-based
- Chlorella Microalgae
- Acrylates
- Poly(Vinyl Formal)
- 2-hydroxyethyl-methacrylate (HEMA)
- Phenylacetylene
- Micro/nano-particles
- Biological Molecules
- Bioinks
- Poly(Acrylic Acid)
- Polyethylene glycol (PEG) based
- α-Bioink
- Heparin
- sulfobetaine methacrylate (SBMA)
- Collagen
- Elastin
- Gelatin
- Matrigel
- Gellan Gum
- Methacrylated Chitosan
- Methacrylated hyaluronic acid (HAMA)
- Pectin
- Xanthan Gum
- Silk Fibroin
- Pyrogallol
- Paeoniflorin
- Fibronectin
- Fibrinogen
- Fibrin
- (2-Hydroxypropyl)methacrylamide (HPMA)
- Methacrylated Collagen (CollMA)
- Carrageenan
- Glucosamine
- Chitosan
- Glycerol
- Poly(glycidol)
- Alginate
- Agarose
- Gelatin-Methacryloyl (GelMA)
- methacrylated chondroitin sulfate (CSMA)
- carboxybetaine acrylamide (CBAA)
- Cellulose
- Novogel
- Methacrylated Silk Fibroin
- Pantoan Methacrylate
- Hyaluronic Acid
- Peptide gel
- Ceramics
- Metals
- Decellularized Extracellular Matrix (dECM)
- Solid Dosage Drugs
- Bioprinting Technologies
- Bioprinting Applications
AUTHOR
Year
2018
Journal/Proceedings
Advanced Materials
Reftype
DOI/URL
DOI
Groups
AbstractAbstract Mechanical gradients are useful to reduce strain mismatches in heterogeneous materials and thus prevent premature failure of devices in a wide range of applications. While complex graded designs are a hallmark of biological materials, gradients in manmade materials are often limited to 1D profiles due to the lack of adequate fabrication tools. Here, a multimaterial 3D‐printing platform is developed to fabricate elastomer gradients spanning three orders of magnitude in elastic modulus and used to investigate the role of various bioinspired gradient designs on the local and global mechanical behavior of synthetic materials. The digital image correlation data and finite element modeling indicate that gradients can be effectively used to manipulate the stress state and thus circumvent the weakening effect of defect‐rich interfaces or program the failure behavior of heterogeneous materials. Implementing this concept in materials with bioinspired designs can potentially lead to defect‐tolerant structures and to materials whose tunable failure facilitates repair of biomedical implants, stretchable electronics, or soft robotics.
AUTHOR
Title
Bioprinting and plastic compression of large pigmented and vascularized human dermo-epidermal skin substitutes by means of a new robotic platform
[Abstract]
Year
2022
Journal/Proceedings
Journal of Tissue Engineering
Reftype
Groups
AbstractExtensive availability of engineered autologous dermo-epidermal skin substitutes (DESS) with functional and structural properties of normal human skin represents a goal for the treatment of large skin defects such as severe burns. Recently, a clinical phase I trial with this type of DESS was successfully completed, which included patients own keratinocytes and fibroblasts. Yet, two important features of natural skin were missing: pigmentation and vascularization. The first has important physiological and psychological implications for the patient, the second impacts survival and quality of the graft. Additionally, accurate reproduction of large amounts of patient’s skin in an automated way is essential for upscaling DESS production. Therefore, in the present study, we implemented a new robotic unit (called SkinFactory) for 3D bioprinting of pigmented and pre-vascularized DESS using normal human skin derived fibroblasts, blood- and lymphatic endothelial cells, keratinocytes, and melanocytes. We show the feasibility of our approach by demonstrating the viability of all the cells after printing in vitro, the integrity of the reconstituted capillary network in vivo after transplantation to immunodeficient rats and the anastomosis to the vascular plexus of the host. Our work has to be considered as a proof of concept in view of the implementation of an extended platform, which fully automatize the process of skin substitution: this would be a considerable improvement of the treatment of burn victims and patients with severe skin lesions based on patients own skin derived cells.
AUTHOR
Title
Development of bioactive catechol functionalized nanoparticles applicable for 3D bioprinting
[Abstract]
Year
2021
Journal/Proceedings
Materials Science and Engineering: C
Reftype
Groups
AbstractEfficient wound treatments to target specific events in the healing process of chronic wounds constitute a significant aim in regenerative medicine. In this sense, nanomedicine can offer new opportunities to improve the effectiveness of existing wound therapies. The aim of this study was to develop catechol bearing polymeric nanoparticles (NPs) and to evaluate their potential in the field of wound healing. Thus, NPs wound healing promoting activities, potential for drug encapsulation and controlled release, and further incorporation in a hydrogel bioink formulation to fabricate cell-laden 3D scaffolds are studied. NPs with 2 and 29 M % catechol contents (named NP2 and NP29) were obtained by nanoprecipitation and presented hydrodynamic diameters of 100 and 75 nm respectively. These nanocarriers encapsulated the hydrophobic compound coumarin-6 with 70% encapsulation efficiency values. In cell culture studies, the NPs had a protective effect in RAW 264.7 macrophages against oxidative stress damage induced by radical oxygen species (ROS). They also presented a regulatory effect on the inflammatory response of stimulated macrophages and promoted upregulation of the vascular endothelial growth factor (VEGF) in fibroblasts and endothelial cells. In particular, NP29 were used in a hydrogel bioink formulation using carboxymethyl chitosan and hyaluronic acid as polymeric matrices. Using a reactive mixing bioprinting approach, NP-loaded hydrogel scaffolds with good structural integrity, shape fidelity and homogeneous NPs dispersion, were obtained. The in vitro catechol NPs release profile of the printed scaffolds revealed a sustained delivery. The bioprinted scaffolds supported viability and proliferation of encapsulated L929 fibroblasts over 14 days. We envision that the catechol functionalized NPs and resulting bioactive bioink presented in this work offer promising advantages for wound healing applications, as they: 1) support controlled release of bioactive catechol NPs to the wound site; 2) can incorporate additional therapeutic functions by co-encapsulating drugs; 3) can be printed into 3D scaffolds with tailored geometries based on patient requirements.
AUTHOR
Title
Multimaterial magnetically assisted 3D printing of composite materials
Year
2015
Journal/Proceedings
Nature Communications
Reftype
DOI/URL
DOI