APPLICATION NOTES
BROCHURES / DOCUMENTATION
SCIENTIFIC PUBLICATIONS
You are researching: Innotere
Cell Type
Tissue and Organ Biofabrication
Skin Tissue Engineering
Drug Delivery
Biological Molecules
Solid Dosage Drugs
Stem Cells
Personalised Pharmaceuticals
Inducend Pluripotent Stem Cells (IPSCs)
Drug Discovery
Cancer Cell Lines
All Groups
- Bioprinting Applications
- Cell Type
- Hepatocytes
- Myoblasts
- Pericytes
- Epicardial Cells
- Cancer Cell Lines
- Bacteria
- Extracellular Vesicles
- Articular cartilage progenitor cells (ACPCs)
- Tenocytes
- Monocytes
- Mesothelial cells
- Nucleus Pulposus Cells
- Osteoblasts
- Neutrophils
- Adipocytes
- Smooth Muscle Cells
- Epithelial
- T cells
- Organoids
- Human Umbilical Vein Endothelial Cells (HUVECs)
- Meniscus Cells
- Synoviocytes
- Stem Cells
- Spheroids
- Skeletal Muscle-Derived Cells (SkMDCs)
- Keratinocytes
- Macrophages
- Human Trabecular Meshwork Cells
- Neurons
- Endothelial
- CardioMyocites
- Melanocytes
- Retinal
- Corneal Stromal Cells
- Annulus Fibrosus Cells
- Chondrocytes
- Embrionic Kidney (HEK)
- Astrocytes
- Fibroblasts
- β cells
- Institution
- Myiongji University
- Harbin Institute of Technology
- Technical University of Berlin
- Institute for Bioengineering of Catalonia (IBEC)
- University of Michigan – School of Dentistry
- University of Applied Sciences Northwestern Switzerland
- Anhui Polytechnic
- University Children's Hospital Zurich
- University of Amsterdam
- University of Tel Aviv
- University of Michigan, Biointerfaces Institute
- Abu Dhabi University
- Jiao Tong University
- University of Aveiro
- Bayreuth University
- Aschaffenburg University
- Sree Chitra Tirunal Institute
- University of Sheffield
- University of Michigan – Biointerfaces Institute
- Ghent University
- Chiao Tung University
- Kaohsiung Medical University
- DTU – Technical University of Denmark
- University of Taiwan
- National University of Singapore
- CIC biomaGUNE
- Baylor College of Medicine
- INM – Leibniz Institute for New Materials
- National Yang Ming Chiao Tung University
- University of Vilnius
- Adolphe Merkle Institute Fribourg
- Halle-Wittenberg University
- L'Oreal
- Tiangong University
- Xi’an Children’s Hospital
- Zurich University of Applied Sciences (ZHAW)
- Innotere
- University of Bordeaux
- Innsbruck University
- DWI – Leibniz Institute
- ETH Zurich
- Hallym University
- Nanjing Medical University
- KU Leuven
- Politecnico di Torino
- Nanyang Technological University
- National Institutes of Health (NIH)
- Ningbo Institute of Materials Technology and Engineering (NIMTE)
- Veterans Administration Medical Center
- University of Minnesota
- Utrecht Medical Center (UMC)
- Rizzoli Orthopaedic Institute
- Queen Mary University
- Hong Kong University
- University of Barcelona
- Chinese Academy of Sciences
- ENEA
- University of Manchester
- University of Bucharest
- Royal Free Hospital
- Rice University
- Jiangsu University
- Rowan University
- University of Nottingham
- University of Geneva
- SINTEF
- Hefei University
- Leibniz University Hannover
- Trinity College
- Novartis
- University of Central Florida
- Helmholtz Institute for Pharmaceutical Research Saarland
- Leipzig University
- Chalmers University of Technology
- Karlsruhe institute of technology
- University of Freiburg
- University of Toronto
- Brown University
- Polish Academy of Sciences
- AO Research Institute (ARI)
- Shanghai University
- Univerity of Hong Kong
- Montreal University
- Shandong Medical University
- University of Wurzburg
- Technical University of Dresden
- University of Nantes
- Biomaterials & Bioinks
- Application
- Tissue Models – Drug Discovery
- Industrial
- Biomaterial Processing
- In Vitro Models
- Robotics
- Drug Discovery
- Medical Devices
- Electronics – Robotics – Industrial
- Tissue and Organ Biofabrication
- Muscle Tissue Engineering
- Intervertebral Disc (IVD) Tissue Engineering
- Liver tissue Engineering
- Cartilage Tissue Engineering
- Dental Tissue Engineering
- Bone Tissue Engineering
- Urethra Tissue Engineering
- Drug Delivery
- Uterus Tissue Engineering
- Gastric Tissue Engineering
- Skin Tissue Engineering
- Nerve – Neural Tissue Engineering
- Meniscus Tissue Engineering
- Heart – Cardiac Patches Tissue Engineering
- Adipose Tissue Engineering
- Trachea Tissue Engineering
- Ocular Tissue Engineering
- BioSensors
- Personalised Pharmaceuticals
- Bioelectronics
- Review Paper
- Printing Technology
- Biomaterial
- Micro/nano-particles
- Biological Molecules
- Bioinks
- Glycerol
- Poly(glycidol)
- Alginate
- Agarose
- Gelatin-Methacryloyl (GelMA)
- methacrylated chondroitin sulfate (CSMA)
- carboxybetaine acrylamide (CBAA)
- Cellulose
- Novogel
- Methacrylated Silk Fibroin
- Pantoan Methacrylate
- Hyaluronic Acid
- Peptide gel
- Poly(Acrylic Acid)
- Polyethylene glycol (PEG) based
- α-Bioink
- Heparin
- sulfobetaine methacrylate (SBMA)
- Collagen
- Elastin
- Gelatin
- Matrigel
- Gellan Gum
- Methacrylated Chitosan
- Methacrylated hyaluronic acid (HAMA)
- Pectin
- Xanthan Gum
- Silk Fibroin
- Pyrogallol
- Paeoniflorin
- Fibronectin
- Fibrinogen
- Fibrin
- (2-Hydroxypropyl)methacrylamide (HPMA)
- Methacrylated Collagen (CollMA)
- Carrageenan
- Glucosamine
- Chitosan
- Ceramics
- Metals
- Decellularized Extracellular Matrix (dECM)
- Solid Dosage Drugs
- Thermoplastics
- Coaxial Extruder
- Non-cellularized gels/pastes
- Paraffin
- Pluronic – Poloxamer
- Polyisobutylene
- Polyphenylene Oxide
- Ionic Liquids
- Silicone
- Konjac Gum
- Polyvinylpyrrolidone (PVP)
- Gelatin-Sucrose Matrix
- Salt-based
- Chlorella Microalgae
- Acrylates
- Poly(Vinyl Formal)
- 2-hydroxyethyl-methacrylate (HEMA)
- Phenylacetylene
- Salecan
- Magnetorheological fluid (MR fluid – MRF)
- Poly(vinyl alcohol) (PVA)
- Jeffamine
- Poly(methyl methacrylate) (PMMA)
- PEDOT
- SEBS
- Polypropylene Oxide (PPO)
- Polyethylene
- Sucrose Acetate
- Polyhydroxybutyrate (PHB)
- Carbopol
- Epoxy
- Poly(itaconate-co-citrate-cooctanediol) (PICO)
- poly (ethylene-co -vinyl acetate) (PEVA)
- Mineral Oil
- poly(octanediol-co-maleic anhydride-co-citrate) (POMaC)
- Poly(N-isopropylacrylamide) (PNIPAAm)
- Poly(Oxazoline)
- 2-hydroxyethyl) methacrylate (HEMA)
- Zein
- Acrylamide
- Poly(trimethylene carbonate)
- Bioprinting Technologies
AUTHOR
Title
Strontium(II) and mechanical loading additively augment bone formation in calcium phosphate scaffolds
[Abstract]
Year
2017
Journal/Proceedings
Journal of Orthopaedic Research
Reftype
DOI/URL
DOI
Groups
AbstractCalcium phosphate cements (CPCs) are widely used for bone-defect treatment. Current developments comprise the fabrication of porous scaffolds by three-dimensional plotting and doting using biologically active substances, such as strontium. Strontium is known to increase osteoblast activity and simultaneously to decrease osteoclast resorption. This study investigated the short- and long-term in vivo performances of strontium(II)-doted CPC (SrCPC) scaffolds compared to non-doted CPC scaffolds after implantation in unloaded or load-bearing trabecular bone defects in sheep. After 6 weeks, both CPC and SrCPC scaffolds exhibited good biocompatibility and osseointegration. Fluorochrome labeling revealed that both scaffolds were penetrated by newly formed bone already after 4 weeks. Neither strontium doting nor mechanical loading significantly influenced early bone formation. In contrast, after 6 months, bone formation was significantly enhanced in SrCPC compared to CPC scaffolds. Energy dispersive X-ray analysis demonstrated the release of strontium from the SrCPC into the bone. Strontium addition did not significantly influence material resorption or osteoclast formation. Mechanical loading significantly stimulated bone formation in both CPC and SrCPC scaffolds after 6 months without impairing scaffold integrity. The most bone was found in SrCPC scaffolds under load-bearing conditions. Concluding, these results demonstrate that strontium doting and mechanical loading additively stimulated bone formation in CPC scaffolds and that the scaffolds exhibited mechanical stability under moderate load, implying good clinical suitability. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res