Biomaterials

BIOMATERIALS

Our 3DDiscovery™ and BioFactory™ bioprinters offer a broad portfolio of biomaterials for both soft and hard tissue engineering and drug discovery.
This portfolio is comprised of natural and synthetic hydrogels acting as extracellular-matrix environments to support cell growth (ECM-BioInk™), biomaterials for scaffolding to mimic hard tissues (OsteoInk™) and support materials (STARK™).

OUR BIOMATERIALS AT A GLANCE:

BiomaterialsApplicationCharacteristics

HYDROGELSECM-a BioInk™ 3D Cell culture, migration and proliferation assayBiosynthetic extracellular matrix with Low net charge
ECM-b BioInk™ Biosynthetic extracellular matrix with Mid net charge
ECM-c BioInk™ Biosynthetic charge extracellular matrix with High net
ECM-f BioInk™ Biosynthetic extracellular matrix with Low net charge Functionalized
ECM-p BioInk™ Biosynthetic extracellular matrix with Low net charge Functionalized

SCAFFOLDINGOsteoInk™ Calcium Phosphate biomaterial for hard tissue engineeringCalcium phospahte formulation

SUPPORTSTARK™ Support material for Freeform FabricationSilicon-based polymer

Biosynthetic Hydrogels

ECM-BioInk™, is a peptide nanofiber 3-dimensional scaffold that promotes cell growth and migration.
It utilizes specific peptides that self-assemble from ECM-BioInk™ fluid precursors into highly intertwined hydrated peptide hydrogel fibres when presented with ionic strengths. By inducing a rapid transformation from solution to gel, a peptide nanofiber scaffold is generated.

The ECM-BioInk™ portfolio contains 5 formulations that differ from each other in the electrical net charge which impacts the matrix stiffness and consequently cell proliferation capacity.

ECM- BioInk’s unique properties

  • Synthetic (highly reproducible with no batch to batch variation)
  • Adaptable matrix stiffness
  • Biological building blocks
  • Animal free
  • Mass transport of nutrients
  • Oxygen diffusion
  • Bulk distribution of proteins and grow factors
  • Optically transparent
  • Neutral pH
  • Ready to use with cells
  • Electrical net charge modulation


ECM-alpha BioInk™

ECM-beta BioInk™

ECM-p BioInk™


By adjusting the concentration of the ECM-BioInk™ solution, users can control the flexibility of the 3D architecture to meet their application′s specific needs. ECM-BioInk™ is a unique human relevant, synthetic extracellular matrix in which scaffold interaction with cells and small molecules are driven by hydrogen and hydrophobic interactions.

SELECT YOUR ECM-BIOINK™ FORMULATION:

Cell typeECM- a BioInk™ECM- b BioInk™ECM-c BioInk™ECM-f BioInk™ECM-f BioInk™Experiment
FibroblastsProliferation, Migration
Human Embryonic Stem CellsProliferation,
Differentiation
Human Induced Pluripotent Stem CellsProliferation,
Differentiation
Human Mesenchemical Stem CellsProliferation,
Differentiation
Bone Marrow Derived Mesenchemial Stem CellsProliferation,
Differentiation
Adipose Tissue Derived Mesenchemical Stem CellsProliferation,
Differentiation
Human Haemopoetic Stem CellsProliferation,
Differentiation
Human Neuronal Stem CellsProliferation,
Differentiation
Cardiac Progenitor CellsProliferation,
Differentiation
Human Endothelial CellsProliferation, Migration
Primary NeuronsProliferation, Migration
CardiomyocytesProliferation, Migration
Nucleus Pulposus CellsProliferation, Migration
HepatocytesProliferation, Migration
ChrondrocytesProliferation, Migration
MyocytesProliferation, Migration
OrderOrderOrderOrderOrder

OsteoInk™

CALCIUM PHOSPHATE MATERIAL FOR 3D TISSUE PRINTING

OsteoInk™ is a ready-to-use calcium phosphate paste for scaffolding and structural engineering. OsteoInk™ is a highly osteoconductive biomaterial close to the chemical composition of human bone. Dedicated to hard tissue engineering such as bone, cartilage or structural scaffold manufacturing, OsteoInk™ can be combined during the printing process with our biomaterial product portfolio (e.g ECM-BioInk™) to create complex 3D tissue models.
The uniqueness of BioFactory™ and 3DDiscovery™ printers enables freeform fabrication of tissue models with controlled layers, pore structure and biological composition. It enables scientists to mimic nature by combining OsteoInk™ with hydrogels (natural or synthetic), bioactives, scaffolding or support materials.

FACTS

  • Designed for BioFactory™ and 3DDiscovery™ tissue printers
  • Osteoconductive calcium phosphate material
  • For Research and Development
  • Available in 5cc cartridge
  • Can be combined with BioInk™, STARK or any other type of bioactives and/or biomaterials

Cartouche_OsteoInk
impression 3DDiscovery OsteoInk

BioInk™

Biosynthetic extracellular matrix

BioInk™ is a chemically-defined hydrogel to support growth of different cell types. It allows cell adhesion, mimics the natural extracellular matrix and is biodegradable. BioInk™ is provided as a ready-to-use chemically-defined hydrogel to print 3D tissue models. Exclusively designed for regenHU’s BioFactory™ and 3DDiscovery™ tissue and bio-printers.

A versatile, chemically-defined hydrogel, supporting cell attachment, growth, differentiation and migration. The BioInk™ is suitable for long-term tissue cultivation (in vitro human dermis for up to 7 weeks).

Modular Matrix Tailored to the needs of your cells
Combined with BioFactory™ or 3DDiscovery™ tissue printers, you will be able to create composite tissue models in a layer-by-layer fashioning with spatial control of bioactive components (matrix, cells, proteins) and biomaterials.

BioInk
BioInk

STARK™

3D SHAPE FIDELITY FOR BIOMIMICS | BIOPOLYMER FOR SCAFFOLDING SUPPORT

Creation of tissue models of complex bioarchitectures and overhanging structures, in single or composite materials, may require fugitive support materials that act as a temporary scaffold for the structure.

Especially in 3D cell culture & LifeScience applications where extracellular matrix materials (ECM) such as low-viscose hydrogels, collagens or similar are used to encapsulate and deliver bioactives, STARK™ biopolymer enables 3D shape fidelity and bioarchitecture control of cell-laden conceptions.

STARK™ is a biocompatible biopolymer dedicated to hard & soft tissue engineering with either a 3DDiscovery™ or BioFactory™ bioprinting platform. It can be used during the construction process in combination with BioInk™ or OsteoInk™ or any natural or synthetic printable biomaterials.

FACTS

  • Designed for 3DDiscovery™ & BioFactory™ bioprinters
  • Cell friendly biocompatible support material, flexible/soft and controlled hardening
  • For Research & Development
  • Thermosensitive cross-linking
  • Can be combined with any printable biomaterial in single process approach
  • Exploit full potential with Bioprinting Software Suite (BioCAM™, BioCUT™)
  • Available in 3cc cartridges, ready to use single component cartridge

Stark