Our 3DDiscovery™ and BioFactory™ bioprinters offer a broad portfolio of biomaterials for both soft and hard tissue engineering and drug discovery.
This portfolio is comprised of natural and synthetic hydrogels acting as extracellular-matrix environments to support cell growth (ECM-BioInk™), biomaterials for scaffolding to mimic hard tissues (OsteoInk™) and support materials (STARK™).
OUR BIOMATERIALS AT A GLANCE:
|HYDROGELS||ECM-a BioInk™||3D Cell culture, migration and proliferation assay||Biosynthetic extracellular matrix with Low net charge|
|ECM-b BioInk™||Biosynthetic extracellular matrix with Mid net charge|
|ECM-c BioInk™||Biosynthetic charge extracellular matrix with High net|
|ECM-f BioInk™||Biosynthetic extracellular matrix with Low net charge Functionalized
|ECM-p BioInk™||Biosynthetic extracellular matrix with Low net charge Functionalized|
|SCAFFOLDING||OsteoInk™||Calcium Phosphate biomaterial for hard tissue engineering||Calcium phospahte formulation|
|SUPPORT||STARK™||Support material for Freeform Fabrication||Silicon-based polymer|
ECM-BioInk™, is a peptide nanofiber 3-dimensional scaffold that promotes cell growth and migration.
It utilizes specific peptides that self-assemble from ECM-BioInk™ fluid precursors into highly intertwined hydrated peptide hydrogel fibres when presented with ionic strengths. By inducing a rapid transformation from solution to gel, a peptide nanofiber scaffold is generated.
The ECM-BioInk™ portfolio contains 5 formulations that differ from each other in the electrical net charge which impacts the matrix stiffness and consequently cell proliferation capacity.
ECM- BioInk’s unique properties
- Synthetic (highly reproducible with no batch to batch variation)
- Adaptable matrix stiffness
- Biological building blocks
- Animal free
- Mass transport of nutrients
- Oxygen diffusion
- Bulk distribution of proteins and grow factors
- Optically transparent
- Neutral pH
- Ready to use with cells
- Electrical net charge modulation
By adjusting the concentration of the ECM-BioInk™ solution, users can control the flexibility of the 3D architecture to meet their application′s specific needs. ECM-BioInk™ is a unique human relevant, synthetic extracellular matrix in which scaffold interaction with cells and small molecules are driven by hydrogen and hydrophobic interactions.
SELECT YOUR ECM-BIOINK™ FORMULATION:
|Cell type||ECM- a BioInk™||ECM- b BioInk™||ECM-c BioInk™||ECM-f BioInk™||ECM-f BioInk™||Experiment
|Human Embryonic Stem Cells||•||•||•||•||•||Proliferation,
|Human Induced Pluripotent Stem Cells||•||•||•||•||•||Proliferation,
|Human Mesenchemical Stem Cells||•||•||•||•||•||Proliferation,
|Bone Marrow Derived Mesenchemial Stem Cells||•||•||•||•||Proliferation,
|Adipose Tissue Derived Mesenchemical Stem Cells||•||•||•||•||Proliferation,
|Human Haemopoetic Stem Cells||•||•||•||•||Proliferation,
|Human Neuronal Stem Cells||•||•||•||Proliferation,
|Cardiac Progenitor Cells||•||•||•||•||•||Proliferation,
|Human Endothelial Cells||•||•||•||Proliferation, Migration|
|Primary Neurons||•||•||•||•||Proliferation, Migration|
|Nucleus Pulposus Cells||•||•||•||Proliferation, Migration|
CALCIUM PHOSPHATE MATERIAL FOR 3D TISSUE PRINTING
OsteoInk™ is a ready-to-use calcium phosphate paste for scaffolding and structural engineering. OsteoInk™ is a highly osteoconductive biomaterial close to the chemical composition of human bone. Dedicated to hard tissue engineering such as bone, cartilage or structural scaffold manufacturing, OsteoInk™ can be combined during the printing process with our biomaterial product portfolio (e.g ECM-BioInk™) to create complex 3D tissue models.
The uniqueness of BioFactory™ and 3DDiscovery™ printers enables freeform fabrication of tissue models with controlled layers, pore structure and biological composition. It enables scientists to mimic nature by combining OsteoInk™ with hydrogels (natural or synthetic), bioactives, scaffolding or support materials.
- Designed for BioFactory™ and 3DDiscovery™ tissue printers
- Osteoconductive calcium phosphate material
- For Research and Development
- Available in 5cc cartridge
- Can be combined with BioInk™, STARK or any other type of bioactives and/or biomaterials
Biosynthetic extracellular matrix
BioInk™ is a chemically-defined hydrogel to support growth of different cell types. It allows cell adhesion, mimics the natural extracellular matrix and is biodegradable. BioInk™ is provided as a ready-to-use chemically-defined hydrogel to print 3D tissue models. Exclusively designed for regenHU’s BioFactory™ and 3DDiscovery™ tissue and bio-printers.
A versatile, chemically-defined hydrogel, supporting cell attachment, growth, differentiation and migration. The BioInk™ is suitable for long-term tissue cultivation (in vitro human dermis for up to 7 weeks).
Modular Matrix Tailored to the needs of your cells
Combined with BioFactory™ or 3DDiscovery™ tissue printers, you will be able to create composite tissue models in a layer-by-layer fashioning with spatial control of bioactive components (matrix, cells, proteins) and biomaterials.
3D SHAPE FIDELITY FOR BIOMIMICS | BIOPOLYMER FOR SCAFFOLDING SUPPORT
Creation of tissue models of complex bioarchitectures and overhanging structures, in single or composite materials, may require fugitive support materials that act as a temporary scaffold for the structure.
Especially in 3D cell culture & LifeScience applications where extracellular matrix materials (ECM) such as low-viscose hydrogels, collagens or similar are used to encapsulate and deliver bioactives, STARK™ biopolymer enables 3D shape fidelity and bioarchitecture control of cell-laden conceptions.
STARK™ is a biocompatible biopolymer dedicated to hard & soft tissue engineering with either a 3DDiscovery™ or BioFactory™ bioprinting platform. It can be used during the construction process in combination with BioInk™ or OsteoInk™ or any natural or synthetic printable biomaterials.
- Designed for 3DDiscovery™ & BioFactory™ bioprinters
- Cell friendly biocompatible support material, flexible/soft and controlled hardening
- For Research & Development
- Thermosensitive cross-linking
- Can be combined with any printable biomaterial in single process approach
- Exploit full potential with Bioprinting Software Suite (BioCAM™, BioCUT™)
- Available in 3cc cartridges, ready to use single component cartridge